REPS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REPS2_MOUSE
• UniProt AC: Q80XA6
• Protein Name: RalBP1-associated Eps domain-containing protein 2
• Gene Name: Reps2
• Organism: Mus musculus (Mouse).
• Sequence Length: 521
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in growth factor signaling through its influence on the Ral signaling pathway (By similarity). Interaction with ASAP1 may regulate cell migration..
• Protein Sequence: MSKNDGEIRFGNPAELHGPKVQIPYLTTEKNSFKRMDNEDKQQETQSPTMSPLASPPSSPPHYQRVSLSHGYSKLRSGTEQMHPAPYERQPIGQPEGPSSEGPGAKPFRRQASLIRSFSVEREPQENNSNYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLSEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKSKWECAIFDSYSESMPANQQSCDLNRMEKTSVKDVADFPVPTQDVTTADDKQALKSTVNESLPKDVSEDTATSKDYNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFLPSAPAANSGLLPPPPALPPRPCPTQSEPVSEADLHSQLNRAPSQAAESSPTKMDAPHAQPPSKPIRRKFRPENQTTESQEPAAAVGGAVSAAMVKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	GPKVQIPYLTTEKNS CCCEECCEEECCCCC	20.50	21454597
28	Phosphorylation	VQIPYLTTEKNSFKR EECCEEECCCCCCCC	42.22	21454597
45	Phosphorylation	NEDKQQETQSPTMSP CCHHHHCCCCCCCCC	29.97	26643407
47	Phosphorylation	DKQQETQSPTMSPLA HHHHCCCCCCCCCCC	29.74	26643407
49	Phosphorylation	QQETQSPTMSPLASP HHCCCCCCCCCCCCC	35.21	26643407
51	Phosphorylation	ETQSPTMSPLASPPS CCCCCCCCCCCCCCC	21.17	26643407
55	Phosphorylation	PTMSPLASPPSSPPH CCCCCCCCCCCCCCC	45.05	26643407
58	Phosphorylation	SPLASPPSSPPHYQR CCCCCCCCCCCCCEE	59.88	26643407
59	Phosphorylation	PLASPPSSPPHYQRV CCCCCCCCCCCCEEE	48.50	26643407
63	Phosphorylation	PPSSPPHYQRVSLSH CCCCCCCCEEEEHHH	12.09	26643407
67	Phosphorylation	PPHYQRVSLSHGYSK CCCCEEEEHHHCCHH	26.75	29899451
72	Phosphorylation	RVSLSHGYSKLRSGT EEEHHHCCHHCCCCC	9.37	26026062
79	Phosphorylation	YSKLRSGTEQMHPAP CHHCCCCCCCCCCCC	25.04	29899451
113	Phosphorylation	KPFRRQASLIRSFSV CCCHHHHHHHHHHCC	18.91	22324799
117	Phosphorylation	RQASLIRSFSVEREP HHHHHHHHHCCCCCC	18.19	25521595
119	Phosphorylation	ASLIRSFSVEREPQE HHHHHHHCCCCCCCC	25.06	25521595
129	Phosphorylation	REPQENNSNYPDEPW CCCCCCCCCCCCCCC	49.69	22324799
131	Phosphorylation	PQENNSNYPDEPWRI CCCCCCCCCCCCCCC	16.33	30635358
158	Phosphorylation	RSLQPDPSSFISGSV HHCCCCHHHHCCHHH	45.31	29472430
159	Phosphorylation	SLQPDPSSFISGSVA HCCCCHHHHCCHHHH	31.80	29472430
162	Phosphorylation	PDPSSFISGSVAKNF CCHHHHCCHHHHHHC	24.01	29472430
164	Phosphorylation	PSSFISGSVAKNFFT HHHHCCHHHHHHCCC	16.47	29472430
194	Phosphorylation	SDADCDGALTLSEFC CCCCCCCCEEHHHHH	5.54	24719451
239	Phosphorylation	AFPKSKWECAIFDSY HCCCCCCEEEEECCC	20.15	-
240	Phosphorylation	FPKSKWECAIFDSYS CCCCCCEEEEECCCC	3.23	24719451
246	Phosphorylation	ECAIFDSYSESMPAN EEEEECCCCCCCCCH	20.50	24719451
320	Phosphorylation	SLKARPRSRSYSSTS HHHCCCCCCCCCCCC	28.41	29899451
322	Phosphorylation	KARPRSRSYSSTSIE HCCCCCCCCCCCCHH	30.52	22817900
323	Phosphorylation	ARPRSRSYSSTSIEE CCCCCCCCCCCCHHH	12.91	19060867
324	Phosphorylation	RPRSRSYSSTSIEEA CCCCCCCCCCCHHHH	28.52	25521595
325	Phosphorylation	PRSRSYSSTSIEEAM CCCCCCCCCCHHHHH	20.24	29899451
326	Phosphorylation	RSRSYSSTSIEEAMK CCCCCCCCCHHHHHH	27.99	25521595
327	Phosphorylation	SRSYSSTSIEEAMKR CCCCCCCCHHHHHHC	29.92	25521595
340	Phosphorylation	KRGEDPPTPPPRPQK HCCCCCCCCCCCCCC	54.54	29899451
348	Phosphorylation	PPPRPQKTHSRASSL CCCCCCCCCCCCCCC	21.60	29899451
350	Phosphorylation	PRPQKTHSRASSLDL CCCCCCCCCCCCCCC	34.47	22324799
353	Phosphorylation	QKTHSRASSLDLNKV CCCCCCCCCCCCCCC	30.26	22324799
354	Phosphorylation	KTHSRASSLDLNKVF CCCCCCCCCCCCCCC	25.56	25521595
405	Phosphorylation	SQLNRAPSQAAESSP HHHHCCHHHHHHHCC	31.31	22324799
410	Phosphorylation	APSQAAESSPTKMDA CHHHHHHHCCCCCCC	36.57	29899451
411	Phosphorylation	PSQAAESSPTKMDAP HHHHHHHCCCCCCCC	28.26	25521595
413	Phosphorylation	QAAESSPTKMDAPHA HHHHHCCCCCCCCCC	40.73	29472430
424	Phosphorylation	APHAQPPSKPIRRKF CCCCCCCCCCCCHHC	58.72	20415495
466	Phosphorylation	HPTVQKQSSKQKKAI CCCCCCCCHHHHHHH	46.68	-
480	Phosphorylation	IQTAIRKNKEANAVL HHHHHHHCHHHHHHH	37.24	-
492	Phosphorylation	AVLARLNSELQQQLK HHHHHHHHHHHHHHH	44.25	26824392
597	Acetylation	----------------------------------------------------------------------------------- -----------------------------------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REPS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REPS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REPS2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASAP1_MOUSE	Asap1	physical	12149250
ASAP1_HUMAN	ASAP1	physical	12149250
ASAP2_HUMAN	ASAP2	physical	12149250

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND MASSSPECTROMETRY.
PubMed: 17242355