REC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REC8_HUMAN
• UniProt AC: O95072
• Protein Name: Meiotic recombination protein REC8 homolog
• Gene Name: REC8
• Organism: Homo sapiens (Human).
• Sequence Length: 547
• Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere . In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chro
• Protein Description: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity)..
• Protein Sequence: MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRAQLQIRIDMETELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERVEEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIEGERELPEVSRRELDLLIAEEEEAILLEIPRLPPPAPAEVEGIGEALGPEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVPPPPRRRRRRRLLFWDKETQISPEKFQEQLQTRAHCWECPMVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRRELPEEAAAEEERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRISLIPPEERWAWPEVEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLSPRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PNVLQRHTGCFATIW CCHHHHHCCHHHHHH	37.52	26270265
17	Phosphorylation	RHTGCFATIWLAATR HHCCHHHHHHHHHHC	7.76	30108239
23	Phosphorylation	ATIWLAATRGSRLVK HHHHHHHHCCCHHHC	29.92	30108239
148	Phosphorylation	SVDPRLPSPFDIPQI CCCCCCCCCCCHHHH	42.67	-
176	Phosphorylation	EIPPEVPTEPREPER HCCCCCCCCCCCCCC	64.89	-
285	Phosphorylation	ELRLPAPPSPERRPP HHCCCCCCCCCCCCC	65.70	19664994
286	Phosphorylation	LRLPAPPSPERRPPV HCCCCCCCCCCCCCC	38.03	19664994
398	Phosphorylation	RRKIEVPSEIEVPRE HHCCCCCCCCCCCHH	57.28	23403867
410	Phosphorylation	PREALEPSVPLMVSL CHHHCCCCCCEEEEE	27.30	-
499	Phosphorylation	ANREPDFSSLVSPLS HCCCCCHHHHCCCCC	30.09	-
503	Phosphorylation	PDFSSLVSPLSPRRM CCHHHHCCCCCHHHH	25.97	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMC3_HUMAN	SMC3	physical	12759374
SYCP3_HUMAN	SYCP3	physical	12759374
SMC1B_HUMAN	SMC1B	physical	12759374
FANCA_HUMAN	FANCA	physical	28215707

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.