dbPTM

RC3H1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RC3H1_MOUSE
UniProt AC	Q4VGL6
Protein Name	Roquin-1 {ECO:0000305}
Gene Name	Rc3h1 {ECO:0000312\|MGI:MGI:2685397}
Organism	Mus musculus (Mouse).
Sequence Length	1130
Subcellular Localization	Cytoplasm, P-body . Cytoplasmic granule . During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (PubMed:26000482). Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finge
Protein Description	Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs. [PubMed: 23663784]
Protein Sequence	MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTDIELLPVNSALLQLVGAQIPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVGLNSTTQSVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRTVVHGLVDYIQNHSKKGADQQQPPQHSKYKTYMCRDMKQRGGCPRGASCTFAHSQEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAPILSDESAVDLSNRKPPALPNGIASSGSTVTQLIPRGTDPSFDSSLKPVKLDHLSSSAPGSPPDLLESAPKSISALPVNPHPVPPRGPTDLPPMPVTKPIQMVPRGSQLYPAQQADVYYQDPRGSAPAFETAPYQQGMYYTPPPCVSRFVRPPPSAPEPGPPYLDHYSPYLQDRVINSQYGTQPQQYPPMYPAHYDGRRVYPAQSYTREEMFRESPIPIDIPSAAVPSYVPESRERYQQVEGYYPVAPHPAQIRPSYPRDPPYSRLPPPQPHPSLDELHRRRKEIMAQLEERKVISPPPFAPSPTLPPAFHPEEFLDEDLKVAGKYKANDYSQYSPWSCDTIGSYIGTKDAKPKDVVAAGSVEMMNVESKGTREQRLDLQRRAVETSDDDLIPFGDRPTVSRFGAISRTSKTLYQGAGPLQAIAPQGAPTKSINISDYSAYGAHGGWGDSPYSPHANIPPQGHFIEREKMSMAEVASHGKPLLSAEREQLRLELQQLNHQISQQTQLRGLEAVSNRLVLQREVNTLASQPQPPQLPPKWPGMISSEQLSLELHQVEREIGKRTRELSMENQCSVDMKSKLGTSKQAENGQPEPQNKIRTEDLTLTFSDVPNGSALTQENLSLLSNKTSSLNLSEDSEGGGDNNDSQRSGVVSNSAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
460	Phosphorylation	LVPRRPLSASLGQLN CCCCCCCCCCHHCCC	20.63	27087446
462	Phosphorylation	PRRPLSASLGQLNEV CCCCCCCCHHCCCCC	29.65	27087446
515	Phosphorylation	IPRGTDPSFDSSLKP CCCCCCCCCCCCCCC	44.49	21659605
529	Phosphorylation	PVKLDHLSSSAPGSP CEEHHHHCCCCCCCC	20.87	21659605
530	Phosphorylation	VKLDHLSSSAPGSPP EEHHHHCCCCCCCCH	36.56	27087446
531	Phosphorylation	KLDHLSSSAPGSPPD EHHHHCCCCCCCCHH	34.80	27087446
535	Phosphorylation	LSSSAPGSPPDLLES HCCCCCCCCHHHHHH	32.00	27087446
542	Phosphorylation	SPPDLLESAPKSISA CCHHHHHHCCCCCCC	50.25	25777480
689	Phosphorylation	REEMFRESPIPIDIP HHHHHHHCCCCCCCC	24.71	27180971
728	Methylation	APHPAQIRPSYPRDP CCCHHHCCCCCCCCC	11.30	18967269
728	Dimethylation	APHPAQIRPSYPRDP CCCHHHCCCCCCCCC	11.30	-
733	Dimethylation	QIRPSYPRDPPYSRL HCCCCCCCCCCCCCC	61.92	-
733	Methylation	QIRPSYPRDPPYSRL HCCCCCCCCCCCCCC	61.92	18967275
770	Phosphorylation	LEERKVISPPPFAPS HHHCCCCCCCCCCCC	34.05	26824392
777	Phosphorylation	SPPPFAPSPTLPPAF CCCCCCCCCCCCCCC	27.38	26824392
779	Phosphorylation	PPFAPSPTLPPAFHP CCCCCCCCCCCCCCH	57.12	25159016
860	Phosphorylation	LQRRAVETSDDDLIP HHHHHCCCCCCCCCC	30.75	29472430
861	Phosphorylation	QRRAVETSDDDLIPF HHHHCCCCCCCCCCC	26.07	30352176
883	Phosphorylation	RFGAISRTSKTLYQG CCCCCCCCCCCCCCC	27.99	25338131
958	Phosphorylation	SHGKPLLSAEREQLR HCCCCCCHHHHHHHH	35.45	27149854
999	Phosphorylation	VLQREVNTLASQPQP HHHHHHHHHHCCCCC	28.95	26026062
1101	Phosphorylation	LSLLSNKTSSLNLSE HHHHCCCCCCCCCCC	28.00	30635358
1102	Phosphorylation	SLLSNKTSSLNLSED HHHCCCCCCCCCCCC	34.14	30635358
1103	Phosphorylation	LLSNKTSSLNLSEDS HHCCCCCCCCCCCCC	26.89	30635358
1107	Phosphorylation	KTSSLNLSEDSEGGG CCCCCCCCCCCCCCC	37.98	21082442
1110	Phosphorylation	SLNLSEDSEGGGDNN CCCCCCCCCCCCCCC	33.80	25282160
1119	Phosphorylation	GGGDNNDSQRSGVVS CCCCCCCHHHCCCCC	29.62	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
535	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RC3H1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RC3H1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIA1_HUMAN	TIA1	physical	20412057
ICOS_HUMAN	ICOS	physical	20412057
RC3H1_MOUSE	Rc3h1	physical	26496200
AAPK1_MOUSE	Prkaa1	physical	26496200

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RC3H1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1110, ANDMASS SPECTROMETRY.	17242355 [Abstract]