dbPTM

PRS10_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRS10_CAEEL
UniProt AC	O17071
Protein Name	Probable 26S proteasome regulatory subunit 10B
Gene Name	rpt-4
Organism	Caenorhabditis elegans.
Sequence Length	406
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity)..
Protein Sequence	MLLLQFSNMVEPTGPAIVEDERTKALNSYRRKLAECRDIEQKLKDLRKKESEMTKQFDKSENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVVGCRRSINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRAEREFVIDEDFMKAVRKVGDAKRLETKLDYKPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	YVVGCRRSINKEELK EEEEECCCCCHHHHH	15.91	19530675
352	Phosphorylation	FEAVVKLSDGFSAAD CEEEEECCCCCCHHH	29.94	30078680
356	Phosphorylation	VKLSDGFSAADLRNV EECCCCCCHHHHHHH	28.24	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRS10_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRS10_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRS10_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA2_CAEEL	pas-2	physical	14704431
PRS10_CAEEL	rpt-4	physical	14704431
EF1A_CAEEL	eef-1A.1	physical	14704431
PSA3_CAEEL	pas-7	physical	14704431
PRS10_CAEEL	rpt-4	physical	18692475
TPM1_CAEEL	lev-11	physical	18692475
TPM3_CAEEL	lev-11	physical	18692475

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRS10_CAEEL

Related Literatures of Post-Translational Modification