PRP45_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRP45_SCHPO
• UniProt AC: Q09882
• Protein Name: Pre-mRNA-processing protein 45
• Gene Name: prp45
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 557
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing..
• Protein Sequence: MALLSEELSSILPNPDFDDEEEDYVERETSHADERQIGVKFHIPPYGQRKGWFPSSPEDFGDGGAFPEIHVAQYPLDMGRKRSAKSAGNTLALQVTSSGAVDYNAIARQGHEHGELVQASFRDLIPLRARLGVGEISLEKPSDEQKQEVANKTKLALQKILSKQIAQSQPKSAVVQQRDDPVYIRYTPSNQMGQALSKQRIIKMVTAEQDPMEPPKFRHKKVPRGPPSPPPPVLHSPPRKVSAQEQQDWQIPPSISNWKNPKGYTIPLDKRLAADGRGLNDVEINDGFAKFSEALYTVERQAREEVRYRAIMRQKMAEKEKQEKEQRLFMLAQKAREDRMGRNAASSGPSHAKPRSTSVSSEERSRSRAGSFSHHSESENEDEDSEAFRRRQELRRERRRQAEKDLRLSRMGAEKRAKLAEKDRPRDVAERVALGLSKPSMSSDTMIDSRLFNQASGLGSGFQDEDSYNVYDKPWRAAPSSTLYRPGATLSRQVDASAELERITSESRYDVLGNAHKKFKGSDEVVESRAGPVTFEKDIADPFGVDTFLNNVSSKKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
228	Phosphorylation	KVPRGPPSPPPPVLH CCCCCCCCCCCCCCC	53.85	28889911
236	Phosphorylation	PPPPVLHSPPRKVSA CCCCCCCCCCCCCCH	32.22	28889911
371	Phosphorylation	RSRSRAGSFSHHSES HHHHCCCCCCCCCCC	23.69	25720772
373	Phosphorylation	RSRAGSFSHHSESEN HHCCCCCCCCCCCCC	23.22	25720772
376	Phosphorylation	AGSFSHHSESENEDE CCCCCCCCCCCCCCC	37.08	28889911
378	Phosphorylation	SFSHHSESENEDEDS CCCCCCCCCCCCCCH	49.05	25720772
554	Phosphorylation	TFLNNVSSKKT---- HHHHHCCCCCC----	33.61	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRP45_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRP45_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRP45_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
U2AF1_SCHPO	uaf2	physical	11414703
PRP45_SCHPO	prp45	physical	11414703
PPIL1_SCHPO	cyp1	physical	11690648

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; SER-236 ANDSER-376, AND MASS SPECTROMETRY.
PubMed: 18257517