PROD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PROD_HUMAN
• UniProt AC: O43272
• Protein Name: Proline dehydrogenase 1, mitochondrial {ECO:0000305}
• Gene Name: PRODH {ECO:0000312|HGNC:HGNC:9453}
• Organism: Homo sapiens (Human).
• Sequence Length: 600
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Converts proline to delta-1-pyrroline-5-carboxylate..
• Protein Sequence: MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQEAYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	EAYRSRRTWELARSL HHHHHHHHHHHHHHH	23.37	26074081
73	Phosphorylation	RTWELARSLLVLRLC HHHHHHHHHHHHHHH	22.05	26074081
226	Phosphorylation	IEASGRVSDDGFIAI HHHHCCCCCCCEEEE	28.73	29083192
368	Acetylation	QRMDVLAKKATEMGV HHHHHHHHHHHHHCC	38.49	-
415	Phosphorylation	IFNTYQCYLKDAYDN EEEEEEEEEHHCCCC	10.97	24043423
420	Phosphorylation	QCYLKDAYDNVTLDV EEEEHHCCCCEEEEH	20.41	24043423
486	Acetylation	DYVLEELKHNAKAKV HHHHHHHHHHCCCEE	37.79	-
490	Ubiquitination	EELKHNAKAKVMVAS HHHHHHCCCEEEEEC	54.80	-
497	Phosphorylation	KAKVMVASHNEDTVR CCEEEEECCCHHHHH	18.55	29449344
502	Phosphorylation	VASHNEDTVRFALRR EECCCHHHHHHHHHH	13.85	29449344
523	Phosphorylation	HPADHQVYFGQLLGM CCCCCHHHHHHHHHH	8.74	24043423
535	Phosphorylation	LGMCDQISFPLGQAG HHHCCEECCCCCCCC	18.38	24043423
543	Phosphorylation	FPLGQAGYPVYKYVP CCCCCCCCCEEECCC	7.79	24043423
546	Phosphorylation	GQAGYPVYKYVPYGP CCCCCCEEECCCCCC	7.66	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PROD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PROD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PROD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN11_HUMAN	CAPN11	physical	26344197
BRAP_HUMAN	BRAP	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
HSP76_HUMAN	HSPA6	physical	28514442
HSP72_HUMAN	HSPA2	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.