PPK15_SCHPO - dbPTM
PPK15_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPK15_SCHPO
UniProt AC Q9P6P3
Protein Name Serine/threonine-protein kinase ppk15
Gene Name ppk15
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 534
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
Protein Description
Protein Sequence MDSDSPILPLSNNPPAARTHDHSQRNNHARHVSSSGTTLFAPVKPATKKYNYRRVSPHGSYISPLEAMTVKLADTYSICNPKFQFSSEQNPRRPLTKPSEGVHNHGFDNVNHDYVLYVNDLLGTDEGRKYLILDTLGHGTFGQVARCQDLKTQQIVAIKVIKNKPAFYNQCVMEVSILELLNNKYDPEDKRHLIRLYDQFMHKNHLCLVFELLSINLYELIKQNQFRGLHLSLVRSFATQLLSCTSLLKQARIIHCDLKPENILLQDLSSPIVKVIDFGSACHERQTVYTYIQSRFYRSPEVILGLHYNCGIDMWSLGCILAELFLGLPLFPGNSEYNQLCRIVDMLGNPPTWMLEMGKNSKKYYNSGFVNGRKTYELKSIEQFSIENNKTEQPGKQYFGEKTLDAIVLNYPRRKTTPKLTPEEHEERLCFIDFIKQFLELNPLKRWTPDQAKNHPFITGASFSQYCIDKQKPLLTTQRTRNRSHTIGNQAVVPPSLQRASTYVSNEPEEFVHTRPLPQYYPPANENENVDEFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MDSDSPILPL
-----CCCCCCCCCC		38.3929996109
5Phosphorylation---MDSDSPILPLSN
---CCCCCCCCCCCC		20.1429996109
33PhosphorylationNNHARHVSSSGTTLF
CCCCEEECCCCCEEE		16.8028889911
34PhosphorylationNHARHVSSSGTTLFA
CCCEEECCCCCEEEE		31.5325720772
35PhosphorylationHARHVSSSGTTLFAP
CCEEECCCCCEEEEE		32.4325720772
38PhosphorylationHVSSSGTTLFAPVKP
EECCCCCEEEEECCC		24.3325720772
56PhosphorylationKYNYRRVSPHGSYIS
CCCCCCCCCCCCCCC		14.9028889911
60PhosphorylationRRVSPHGSYISPLEA
CCCCCCCCCCCHHHH		19.0928889911
61PhosphorylationRVSPHGSYISPLEAM
CCCCCCCCCCHHHHC		15.2629996109
287PhosphorylationSACHERQTVYTYIQS
HHHCCHHHHHHHHHH		23.0029996109
289PhosphorylationCHERQTVYTYIQSRF
HCCHHHHHHHHHHHH		9.3829996109
290PhosphorylationHERQTVYTYIQSRFY
CCHHHHHHHHHHHHC		15.1528889911
291PhosphorylationERQTVYTYIQSRFYR
CHHHHHHHHHHHHCC		4.5428889911
484PhosphorylationTQRTRNRSHTIGNQA
CCCCCCCCCCCCCCC		28.6529996109
486PhosphorylationRTRNRSHTIGNQAVV
CCCCCCCCCCCCCCC		31.6529996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPK15_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPK15_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPK15_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EME1_SCHPOeme1genetic
18818364
REB1_SCHPOreb1genetic
18818364
YFH9_SCHPOSPAC23A1.09genetic
22681890
OTU2_SCHPOotu2genetic
22681890
ULP2_SCHPOulp2genetic
22681890
YL85_SCHPOdeg1genetic
22681890
YM04_SCHPOSPAC212.04cgenetic
22681890
QCR8_SCHPOqcr8genetic
22681890
PHD1_SCHPOhos2genetic
22681890
ZFS1_SCHPOzfs1genetic
22681890
MSH6_SCHPOmsh6genetic
22681890
YGK4_SCHPOSPBC725.04genetic
22681890
RM39_SCHPOmrpl39genetic
22681890
YBAC_SCHPOrud3genetic
22681890
MET8_SCHPOSPAC4D7.06cgenetic
22681890
YBE8_SCHPOSPBC17D11.08physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPK15_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33; SER-56; SER-60 ANDTYR-291, AND MASS SPECTROMETRY.

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