PLXB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLXB3_HUMAN
• UniProt AC: Q9ULL4
• Protein Name: Plexin-B3
• Gene Name: PLXNB3
• Organism: Homo sapiens (Human).
• Sequence Length: 1909
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Colocalizes with RIT2/RIN at the plasma membrane.
• Protein Description: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1..
• Protein Sequence: MCHAAQETPLLHHFMAPVMARWPPFGLCLLLLLLSPPPLPLTGAHRFSAPNTTLNHLALAPGRGTLYVGAVNRLFQLSPELQLEAVAVTGPVIDSPDCVPFRDPAECPQAQLTDNANQLLLVSSRAQELVACGQVRQGVCETRRLGDVAEVLYQAEDPGDGQFVAANTPGVATVGLVVPLPGRDLLLVARGLAGKLSAGVPPLAIRQLAGSQPFSSEGLGRLVVGDFSDYNNSYVGAFADARSAYFVFRRRGARAQAEYRSYVARVCLGDTNLYSYVEVPLACQGQGLIQAAFLAPGTLLGVFAAGPRGTQAALCAFPMVELGASMEQARRLCYTAGGRGPSGAEEATVEYGVTSRCVTLPLDSPESYPCGDEHTPSPIAGRQPLEVQPLLKLGQPVSAVAALQADGHMIAFLGDTQGQLYKVFLHGSQGQVYHSQQVGPPGSAISPDLLLDSSGSHLYVLTAHQVDRIPVAACPQFPDCASCLQAQDPLCGWCVLQGRCTRKGQCGRAGQLNQWLWSYEEDSHCLHIQSLLPGHHPRQEQGQVTLSVPRLPILDADEYFHCAFGDYDSLAHVEGPHVACVTPPQDQVPLNPPGTDHVTVPLALMFEDVTVAATNFSFYDCSAVQALEAAAPCRACVGSIWRCHWCPQSSHCVYGEHCPEGERTIYSAQEVDIQVRGPGACPQVEGLAGPHLVPVGWESHLALRVRNLQHFRGLPASFHCWLELPGELRGLPATLEETAGDSGLIHCQAHQFYPSMSQRELPVPIYVTQGEAQRLDNTHALYVILYDCAMGHPDCSHCQAANRSLGCLWCADGQPACRYGPLCPPGAVELLCPAPSIDAVEPLTGPPEGGLALTILGSNLGRAFADVQYAVSVASRPCNPEPSLYRTSARIVCVTSPAPNGTTGPVRVAIKSQPPGISSQHFTYQDPVLLSLSPRWGPQAGGTQLTIRGQHLQTGGNTSAFVGGQPCPILEPVCPEAIVCRTRPQAAPGEAAVLVVFGHAQRTLLASPFRYTANPQLVAAEPSASFRGGGRLIRVRGTGLDVVQRPLLSVWLEADAEVQASRAQPQDPQPRRSCGAPAADPQACIQLGGGLLQCSTVCSVNSSSLLLCRSPAVPDRAHPQRVFFTLDNVQVDFASASGGQGFLYQPNPRLAPLSREGPARPYRLKPGHVLDVEGEGLNLGISKEEVRVHIGRGECLVKTLTRTHLYCEPPAHAPQPANGSGLPQFVVQMGNVQLALGPVQYEAEPPLSAFPVEAQAGVGMGAAVLIAAVLLLTLMYRHKSKQALRDYQKVLVQLESLETGVGDQCRKEFTDLMTEMTDLSSDLEGSGIPFLDYRTYAERAFFPGHGGCPLQPKPEGPGEDGHCATVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHGKLEYLTDIMRTLLGDLAAHYVHRNPKLMLRRTETMVEKLLTNWLSICLYAFLREVAGEPLYMLFRAIQYQVDKGPVDAVTGKAKRTLNDSRLLREDVEFQPLTLMVLVGPGAGGAAGSSEMQRVPARVLDTDTITQVKEKVLDQVYKGTPFSQRPSVHALDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVGLVPQLHRGSTISQSLAQRCPLGENIPTLEDGEEGGVCLWHLVKATEEPEGAKVRCSSLREREPARAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPIPIAVKYLFDLLDELAEKHGIEDPGTLHIWKTNSLLLRFWVNALKNPQLIFDVRVSDNVDAILAVIAQTFIDSCTTSEHKVGRDSPVNKLLYAREIPRYKQMVERYYADIRQSSPASYQEMNSALAELSGNYTSAPHCLEALQELYNHIHRYYDQIISALEEDPVGQKLQLACRLQQVAALVENKVTDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	23.63	25219547
7 (in isoform 2)	Phosphorylation	-	47.90	25219547
8 (in isoform 2)	Phosphorylation	-	13.73	25219547
10 (in isoform 2)	Phosphorylation	-	10.43	25219547
12 (in isoform 2)	Phosphorylation	-	21.59	25219547
15 (in isoform 2)	Phosphorylation	-	3.42	25219547
51	N-linked_Glycosylation	AHRFSAPNTTLNHLA CCCCCCCCCCCCCEE	45.47	UniProtKB CARBOHYD
123	Phosphorylation	ANQLLLVSSRAQELV HHHEEEEEHHHHHHH	17.67	24719451
231	N-linked_Glycosylation	VGDFSDYNNSYVGAF EECCCCCCCCEECEE	35.64	UniProtKB CARBOHYD
243	Phosphorylation	GAFADARSAYFVFRR CEEEEHHHHHHHHHC	29.10	27251275
266	Phosphorylation	YRSYVARVCLGDTNL HHHHHHHHHHCCCCC	1.97	27251275
547	Phosphorylation	EQGQVTLSVPRLPIL CCCCEEEECCCCCCC	22.25	24719451
615	N-linked_Glycosylation	DVTVAATNFSFYDCS CEEEEEECCCEECCH	26.32	UniProtKB CARBOHYD
639	Phosphorylation	PCRACVGSIWRCHWC CHHHHCCCCEEEEEC	9.89	24719451
664	Phosphorylation	HCPEGERTIYSAQEV CCCCCCEEEEEEEEE	21.69	24043423
666	Phosphorylation	PEGERTIYSAQEVDI CCCCEEEEEEEEEEE	9.42	24043423
667	Phosphorylation	EGERTIYSAQEVDIQ CCCEEEEEEEEEEEE	21.45	24043423
802	N-linked_Glycosylation	CSHCQAANRSLGCLW CHHHHHHCCCCCCEE	36.77	UniProtKB CARBOHYD
875	Phosphorylation	QYAVSVASRPCNPEP HHHHHHHCCCCCCCC	34.30	24719451
887	Phosphorylation	PEPSLYRTSARIVCV CCCCCCEECEEEEEE	17.12	29255136
888	Phosphorylation	EPSLYRTSARIVCVT CCCCCEECEEEEEEE	13.42	29255136
895	Phosphorylation	SARIVCVTSPAPNGT CEEEEEEECCCCCCC	24.70	29255136
896	Phosphorylation	ARIVCVTSPAPNGTT EEEEEEECCCCCCCC	9.92	29255136
898	Phosphorylation	IVCVTSPAPNGTTGP EEEEECCCCCCCCCC	15.23	24719451
900	N-linked_Glycosylation	CVTSPAPNGTTGPVR EEECCCCCCCCCCEE	63.65	UniProtKB CARBOHYD
902	Phosphorylation	TSPAPNGTTGPVRVA ECCCCCCCCCCEEEE	34.91	29255136
903	Phosphorylation	SPAPNGTTGPVRVAI CCCCCCCCCCEEEEE	40.67	29255136
931	Phosphorylation	YQDPVLLSLSPRWGP ECCCEEEEECCCCCC	23.73	24719451
933	Phosphorylation	DPVLLSLSPRWGPQA CCEEEEECCCCCCCC	14.72	24719451
957	N-linked_Glycosylation	QHLQTGGNTSAFVGG EEEECCCCCCCEECC	32.00	UniProtKB CARBOHYD
1101	N-linked_Glycosylation	CSTVCSVNSSSLLLC EECEEEECCCCEEEE	21.63	UniProtKB CARBOHYD
1218	N-linked_Glycosylation	AHAPQPANGSGLPQF CCCCCCCCCCCCCEE	52.42	UniProtKB CARBOHYD
1289	Ubiquitination	QALRDYQKVLVQLES HHHHHHHHHHHHHHH	31.16	-
1333	Phosphorylation	SGIPFLDYRTYAERA CCCCCCCHHHCCCCC	13.65	24275569
1371	Phosphorylation	ATVRQGLTQLSNLLN HHHHHHHHHHHHHHH	34.00	23403867
1374	Phosphorylation	RQGLTQLSNLLNSKL HHHHHHHHHHHHHHH	18.66	23403867
1379	Phosphorylation	QLSNLLNSKLFLLTL HHHHHHHHHHHHHHH	30.61	23403867
1455	Phosphorylation	TMVEKLLTNWLSICL HHHHHHHHHHHHHHH	34.48	29449344
1459	Phosphorylation	KLLTNWLSICLYAFL HHHHHHHHHHHHHHH	11.67	29449344
1463	Phosphorylation	NWLSICLYAFLREVA HHHHHHHHHHHHHHC	7.30	29449344
1475	Phosphorylation	EVAGEPLYMLFRAIQ HHCCCHHHHHHHHHH	11.50	30257219
1483	Phosphorylation	MLFRAIQYQVDKGPV HHHHHHHHCCCCCCC	12.37	-
1500	Phosphorylation	VTGKAKRTLNDSRLL CCCCCCCCCCCHHHH	29.25	-
1504	Phosphorylation	AKRTLNDSRLLREDV CCCCCCCHHHHHCCC	24.61	-
1570	Phosphorylation	TPFSQRPSVHALDLE CCHHHCCCEEEECCE	28.82	28348404
1580	Phosphorylation	ALDLEWRSGLAGHLT EECCEECCCCCCCCC	38.95	28270605
1587	Phosphorylation	SGLAGHLTLSDEDLT CCCCCCCCCCHHHHH	20.67	28270605
1589	Phosphorylation	LAGHLTLSDEDLTSV CCCCCCCCHHHHHHH	33.45	24719451
1612	Phosphorylation	NTLQHYKVPDGATVG HCCCCCCCCCCCEEE	4.04	24719451
1617	Phosphorylation	YKVPDGATVGLVPQL CCCCCCCEEEECCCC	22.19	28270605
1628	Phosphorylation	VPQLHRGSTISQSLA CCCCCCCCCHHHHHH	23.64	25850435
1629	Phosphorylation	PQLHRGSTISQSLAQ CCCCCCCCHHHHHHH	27.72	25850435
1631	Phosphorylation	LHRGSTISQSLAQRC CCCCCCHHHHHHHHC	17.50	25850435
1633	Phosphorylation	RGSTISQSLAQRCPL CCCCHHHHHHHHCCC	20.91	28060719
1651	Phosphorylation	IPTLEDGEEGGVCLW CCCCCCCCCCCEEEE	66.83	27251275
1652	Phosphorylation	PTLEDGEEGGVCLWH CCCCCCCCCCEEEEE	67.77	24719451
1654	Phosphorylation	LEDGEEGGVCLWHLV CCCCCCCCEEEEEEE	15.39	27251275
1676	Phosphorylation	GAKVRCSSLREREPA CCEEEHHHHCCCCHH	34.76	-
1702	Phosphorylation	RLLSMKGTLQKFVDD HHHHCCCHHHHHCCH	22.09	-
1754	Phosphorylation	LHIWKTNSLLLRFWV EEEEECCHHHHHHHH	26.14	21857030
1793	Phosphorylation	IAQTFIDSCTTSEHK HHHHHHHHCCCCCCC	14.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLXB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLXB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLXB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL7_HUMAN	CUL7	physical	12421765
TICN2_HUMAN	SPOCK2	physical	12421765
ARHGB_HUMAN	ARHGEF11	physical	12421765
MAGI2_HUMAN	MAGI2	physical	12421765
BTBD3_HUMAN	BTBD3	physical	12421765
MAGI3_HUMAN	MAGI3	physical	12421765

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.