| UniProt ID | PLPL9_HUMAN | |
|---|---|---|
| UniProt AC | O60733 | |
| Protein Name | 85/88 kDa calcium-independent phospholipase A2 | |
| Gene Name | PLA2G6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 806 | |
| Subcellular Localization |
Isoform LH-iPLA2: Membrane Peripheral membrane protein. Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. Isoform SH-iPLA2: Cytoplasm. |
|
| Protein Description | Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods.; Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.. | |
| Protein Sequence | MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | FFGRLVNTFSGVTNL CHHHHHHHHCCHHCC | 30622161 | ||
| 12 | Phosphorylation | GRLVNTFSGVTNLFS HHHHHHHCCHHCCCC | 30622161 | ||
| 15 | Phosphorylation | VNTFSGVTNLFSNPF HHHHCCHHCCCCCCC | 25693802 | ||
| 25 | Ubiquitination | FSNPFRVKEVAVADY CCCCCCEEEEEEECC | 30230243 | ||
| 276 | Phosphorylation | EMIISMDSSQIHSKD EEEEECCHHHHCCCC | 29083192 | ||
| 277 | Phosphorylation | MIISMDSSQIHSKDP EEEECCHHHHCCCCC | 29083192 | ||
| 281 | Phosphorylation | MDSSQIHSKDPRYGA CCHHHHCCCCCCCCC | 29083192 | ||
| 295 | Ubiquitination | ASPLHWAKNAEMARM CCCCHHHHHHHHHHH | 29967540 | ||
| 305 | Ubiquitination | EMARMLLKRGCNVNS HHHHHHHHCCCCCCC | - | ||
| 445 | Phosphorylation | RAQPPPISLNNLELQ CCCCCCCCCCCCCHH | - | ||
| 511 | Ubiquitination | SGVATKDLFDWVAGT HCCCCHHHHHHHCCC | 29967540 | ||
| 536 | Phosphorylation | LHSKSMAYMRGMYFR HHHHCHHHHHCCCHH | - | ||
| 541 | Phosphorylation | MAYMRGMYFRMKDEV HHHHHCCCHHHCCCH | 25884760 | ||
| 565 | Ubiquitination | GPLEEFLKREFGEHT CCHHHHHHHHHCCCC | 29967540 | ||
| 573 | Ubiquitination | REFGEHTKMTDVRKP HHHCCCCCCCCCCCC | - | ||
| 636 | Phosphorylation | LVWRAARSSGAAPTY HHHHHHHHCCCCCCE | 23898821 | ||
| 637 | Phosphorylation | VWRAARSSGAAPTYF HHHHHHHCCCCCCEE | 23898821 | ||
| 642 | Phosphorylation | RSSGAAPTYFRPNGR HHCCCCCCEECCCCC | 23898821 | ||
| 643 | Phosphorylation | SSGAAPTYFRPNGRF HCCCCCCEECCCCCC | 23898821 | ||
| 661 | Phosphorylation | GLLANNPTLDAMTEI CCCCCCCCHHHHHHH | 23898821 | ||
| 666 | Phosphorylation | NPTLDAMTEIHEYNQ CCCHHHHHHHHHHHH | 23898821 | ||
| 671 | Ubiquitination | AMTEIHEYNQDLIRK HHHHHHHHHHHHHHH | 29967540 | ||
| 671 | Phosphorylation | AMTEIHEYNQDLIRK HHHHHHHHHHHHHHH | 23898821 | ||
| 688 | Phosphorylation | ANKVKKLSIVVSLGT CCCCEEEEEEEEECC | 21964256 | ||
| 692 | Phosphorylation | KKLSIVVSLGTGRSP EEEEEEEEECCCCCC | 21964256 | ||
| 719 | Ubiquitination | SNPWELAKTVFGAKE CCHHHHHHHHHHHHH | - | ||
| 725 | Ubiquitination | AKTVFGAKELGKMVV HHHHHHHHHHCCEEE | 29967540 | ||
| 729 | Ubiquitination | FGAKELGKMVVDCCT HHHHHHCCEEEEEEE | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PLPL9_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PLPL9_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PLPL9_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PLPL9_HUMAN | PLA2G6 | physical | 15385540 | |
| ARF1_MOUSE | Arf1 | physical | 20881058 |
| Kegg Disease | |
|---|---|
| H00057 | Parkinson's disease (PD) |
| H00833 | Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Pantothenate kin |
| OMIM Disease | |
| 610217 | Neurodegeneration with brain iron accumulation 2B (NBIA2B) |
| 256600 | Neurodegeneration with brain iron accumulation 2A (NBIA2A) |
| 612953 | Parkinson disease 14 (PARK14) |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB01103 | Quinacrine |
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