PLPL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPL4_HUMAN
• UniProt AC: P41247
• Protein Name: Patatin-like phospholipase domain-containing protein 4
• Gene Name: PNPLA4
• Organism: Homo sapiens (Human).
• Sequence Length: 253
• Subcellular Localization: Mitochondrion .
• Protein Description: Lipid hydrolase..
• Protein Sequence: MKHINLSFAACGFLGIYHLGAASALCRHGKKLVKDVKAFAGASAGSLVASVLLTAPEKIEECNQFTYKFAEEIRRQSFGAVTPGYDFMARLRSGMESILPPSAHELAQNRLHVSITNAKTRENHLVSTFSSREDLIKVLLASSFVPIYAGLKLVEYKGQKWVDGGLTNALPILPVGRTVTISPFSGRLDISPQDKGQLDLYVNIAKQDIMLSLANLVRLNQALFPPSKRKMESLYQCGFDDTVKFLLKENWFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	SAGSLVASVLLTAPE CHHHHHHHHHHCCHH	13.06	20068231
54	Phosphorylation	LVASVLLTAPEKIEE HHHHHHHCCHHHHHH	35.69	20068231
116	Phosphorylation	NRLHVSITNAKTREN CCCEEEEECCCCCCC	22.93	17192257
131	Phosphorylation	HLVSTFSSREDLIKV CEEECCCCHHHHHHH	35.18	-
167	Phosphorylation	KWVDGGLTNALPILP EEECCCCCCCCEEEC	23.01	-
178	Phosphorylation	PILPVGRTVTISPFS EEECCCCEEEECCCC	18.97	22817900
182	Phosphorylation	VGRTVTISPFSGRLD CCCEEEECCCCCCCC	15.55	22817900
212	Phosphorylation	AKQDIMLSLANLVRL CHHHHHHHHHHHHHH	14.20	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT2B3_HUMAN	ATP2B3	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	28514442
SNX11_HUMAN	SNX11	physical	28514442
TIGAR_HUMAN	C12orf5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-116, AND MASSSPECTROMETRY.
PubMed: 18691976