dbPTM

PIN1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIN1_SCHPO
UniProt AC	O74448
Protein Name	Peptidyl-prolyl cis-trans isomerase pin1
Gene Name	pin1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	175
Subcellular Localization	Nucleus .
Protein Description	Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1..
Protein Sequence	MSNTGLPKPWIVKISRSRNRPYFFNTETHESLWEPPAATDMAALKKFIANELQESVTPTEASNSPKIRASHLLVKHRESRRPSSWKEEHITRSKEEARKLAEHYEQLLKSGSVSMHDLAMKESDCSSARRGGELGEFGRDEMQKPFEDAAFALKPGEISGVVETSSGFHIIQRHA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	WIVKISRSRNRPYFF EEEEEECCCCCCEEE	27.41	28889911
39	Phosphorylation	LWEPPAATDMAALKK HCCCCCCCCHHHHHH	28.54	28889911
55	Phosphorylation	IANELQESVTPTEAS HHHHHHHCCCCCCCC	20.52	21712547
57	Phosphorylation	NELQESVTPTEASNS HHHHHCCCCCCCCCC	33.50	28889911
62	Phosphorylation	SVTPTEASNSPKIRA CCCCCCCCCCCCCCH	31.44	21712547
64	Phosphorylation	TPTEASNSPKIRASH CCCCCCCCCCCCHHH	25.69	28889911
114	Phosphorylation	LLKSGSVSMHDLAMK HHHHCCCCHHHHHCC	16.46	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIN1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIN1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIN1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MPIP_SCHPO	cdc25	genetic	11707530
WEE1_SCHPO	wee1	genetic	11707530

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIN1_SCHPO

Related Literatures of Post-Translational Modification