PIK1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIK1_SCHPO
• UniProt AC: Q10366
• Protein Name: Phosphatidylinositol 4-kinase pik1
• Gene Name: pik1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 851
• Subcellular Localization: Golgi apparatus . Nucleus.
• Protein Description: Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (By similarity)..
• Protein Sequence: MPSSNSGNELLLRFFESAHFTSQLCVAYLSRYPNNIGIHHFLCEKLATFPYEEIEFFIPQLIHLVLNKDSESVALEEFIISQCEQNTQCALITFWYLQAHMVDLGLQPHSSCFKICKRLYNRIQILVFMSSSSLIQSQQKISENVTPALILSGIMLGGVCVPELLKKAGPIAIAQGRKAPRQDPDESDVDVLRRLSTEPRYSLDVLRSSLNNSIVEQHSEVSLRLKAPELTRTHSYQSSATLSIDEQRRVLRSNYFQQEIQFLFALQDISIRLIIVPRQARLSSLRAELALLNNNLPADVNIPLLRSYHKEVSHKIVRIDPKEATILNSAERVPYLIMVEVLSGELSFEPQSKKNKAKVQKIVSHKNQRKRWFDLTDVDPYTNLQDSTDNDISESESEGGDLSMSPLIKGLVPDTLSLSKSFSSFGNVSLQVPSSHRDTDVVLLSGRHSDSDGNGALKRSKIYASEITARMRAAATMLSQLDAEGSRRPKAETERIKNSIILDMQRLEEERLNEPSIYPVSVDISCAEDLRFGKETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPYGHYPNWDLVSVIVKTGADLRQETFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAISVHSIKKNLTKQLREAELAQGKIAGKNVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSIISYLLQLKDRHNGNVLIDSEGHIIHIDFGFLLTNTPGNVGFESAPFKLTADYLEILDDRFDEYRSLMKAAFKSVRKNADQIILLVEVMQNNSTMPCFRAGENTSAQLLQRFQLQLGDKECDDFVDLLIQKANCSVWTRLYDLFQNITNGIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	PRQDPDESDVDVLRR CCCCCCCCHHHHHHH		25720772
196	Phosphorylation	VDVLRRLSTEPRYSL HHHHHHHCCCCCHHH		25720772
197	Phosphorylation	DVLRRLSTEPRYSLD HHHHHHCCCCCHHHH		29996109
201	Phosphorylation	RLSTEPRYSLDVLRS HHCCCCCHHHHHHHH		29996109
202	Phosphorylation	LSTEPRYSLDVLRSS HCCCCCHHHHHHHHH		28889911
219	Phosphorylation	NSIVEQHSEVSLRLK CHHHHHCCCEEEEEC		28889911
222	Phosphorylation	VEQHSEVSLRLKAPE HHHCCCEEEEECCCC		28889911
235	Phosphorylation	PELTRTHSYQSSATL CCCCCCEEECCCCEE		28889911
236	Phosphorylation	ELTRTHSYQSSATLS CCCCCEEECCCCEEE		28889911
241	Phosphorylation	HSYQSSATLSIDEQR EEECCCCEEEHHHHH		25720772
415	Phosphorylation	IKGLVPDTLSLSKSF HCCCCCCCEECCCCC		25720772
421	Phosphorylation	DTLSLSKSFSSFGNV CCEECCCCCCCCCCE		29996109
423	Phosphorylation	LSLSKSFSSFGNVSL EECCCCCCCCCCEEE		29996109
424	Phosphorylation	SLSKSFSSFGNVSLQ ECCCCCCCCCCEEEE		29996109
429	Phosphorylation	FSSFGNVSLQVPSSH CCCCCCEEEECCCCC		25720772
445	Phosphorylation	DTDVVLLSGRHSDSD CCCEEEEECCCCCCC		29996109
449	Phosphorylation	VLLSGRHSDSDGNGA EEEECCCCCCCCCCC		29996109
451	Phosphorylation	LSGRHSDSDGNGALK EECCCCCCCCCCCCC		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIK1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIK1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIK1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLR4_SCHPO	cdc4	physical	11087749
POT1_SCHPO	pot1	genetic	29410177

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.