PIGP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIGP_HUMAN
• UniProt AC: P57054
• Protein Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
• Gene Name: PIGP
• Organism: Homo sapiens (Human).
• Sequence Length: 158
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis..
• Protein Sequence: MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVPRSTSLTLIVF --CCCCHHHHHHHHH	29.09	-
6	Phosphorylation	--MVPRSTSLTLIVF --CCCCHHHHHHHHH	29.09	-
9	Phosphorylation	VPRSTSLTLIVFLFH CCCHHHHHHHHHHHH	17.76	-
9	Phosphorylation	VPRSTSLTLIVFLFH CCCHHHHHHHHHHHH	17.76	-
19	Phosphorylation	VFLFHRLSKAPGKMV HHHHHHHHCCCCCCC	27.08	-
19	Phosphorylation	VFLFHRLSKAPGKMV HHHHHHHHCCCCCCC	27.08	-
29	Phosphorylation	PGKMVENSPSPLPER CCCCCCCCCCCCCHH	17.16	27732954
31	Phosphorylation	KMVENSPSPLPERAI CCCCCCCCCCCHHHH	38.60	27732954
102	Ubiquitination	VLLFGINMMSTSPLD HHHHCHHHHCCCCCC	1.80	29967540
126	Ubiquitination	AKNQQQKKYQEEAIP HHHHHHHHHHHHHHH	48.07	29967540
157	Ubiquitination	AAKELYTKN------ HHHHHHCCC------	47.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIGP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIGP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIGP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIGA_HUMAN	PIGA	physical	10944123
PIGQ_HUMAN	PIGQ	physical	10944123
ASC_HUMAN	PYCARD	physical	28514442
PIGA_HUMAN	PIGA	physical	28514442
PIGH_HUMAN	PIGH	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.