PHT14_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHT14_ARATH
• UniProt AC: Q96303
• Protein Name: Inorganic phosphate transporter 1-4
• Gene Name: PHT1-4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 534
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: High-affinity transporter for external inorganic phosphate. Acts as a H(+):phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate..
• Protein Sequence: MAREQLQVLNALDVAKTQWYHFTAIIIAGMGFFTDAYDLFCISLVTKLLGRIYYHVEGAQKPGTLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGMTLMVMVLCSIASGLSFGHEPKAVMATLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFVSAVFAMQGFGIMAGGIFAIIISSAFEAKFPSPAYADDALGSTIPQADLVWRIILMAGAIPAAMTYYSRSKMPETARYTALVAKDAKQAASDMSKVLQVEIEPEQQKLEEISKEKSKAFGLFSKEFMSRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPPAQSMNAIQEVFKIARAQTLIALCSTVPGYWFTVAFIDVIGRFAIQMMGFFFMTVFMFALAIPYNHWTHKENRIGFVIMYSLTFFFANFGPNATTFVVPAEIFPARFRSTCHGISAASGKLGAMVGAFGFLYLAQNPDKDKTDAGYPPGIGVRNSLIVLGVVNFLGILFTFLVPESKGKSLEEMSGENEDNENSNNDSRTVPIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	RKKVYGMTLMVMVLC CCCHHHHHHHHHHHH	13.82	24243849
112	Phosphorylation	LMVMVLCSIASGLSF HHHHHHHHHHHCCCC	19.61	24243849
129	Phosphorylation	EPKAVMATLCFFRFW CHHHHHHHHHHHHHH	13.13	19880383
255	Phosphorylation	KDAKQAASDMSKVLQ HHHHHHHHHHHHHHC	36.54	19688752
258	Phosphorylation	KQAASDMSKVLQVEI HHHHHHHHHHHCEEC	25.30	17317660
276	Phosphorylation	QQKLEEISKEKSKAF HHHHHHHHHHHHHHH	37.73	17317660
440	Phosphorylation	FPARFRSTCHGISAA CCHHHHHHHHHHHHH	12.31	19880383
524	Phosphorylation	ENEDNENSNNDSRTV CCCCCCCCCCCCCCC	30.72	19880383
528	Phosphorylation	NENSNNDSRTVPIV- CCCCCCCCCCCCCC-	31.79	17317660

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHT14_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHT14_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHT14_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHT11_ARATH	PHT1;1	physical	25754174
PHT14_ARATH	PHT1;4	physical	25754174

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of nuclei-enriched fractions fromArabidopsis thaliana.";
Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A.,Andreasson E., Rathjen J.P., Peck S.C.;
J. Proteomics 72:439-451(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524, AND MASSSPECTROMETRY.
PubMed: 19245862

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524, AND MASSSPECTROMETRY.
PubMed: 18433157

"Phosphoproteomics of the Arabidopsis plasma membrane and a newphosphorylation site database.";
Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
Plant Cell 16:2394-2405(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.
PubMed: 15308754