PHT11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHT11_ARATH
• UniProt AC: Q8VYM2
• Protein Name: Inorganic phosphate transporter 1-1
• Gene Name: PHT1-1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 524
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: High-affinity transporter for external inorganic phosphate. Acts as a H(+):phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate..
• Protein Sequence: MAEQQLGVLKALDVAKTQLYHFTAIVIAGMGFFTDAYDLFCVSLVTKLLGRIYYFNPESAKPGSLPPHVAAAVNGVALCGTLSGQLFFGWLGDKLGRKKVYGLTLVMMILCSVASGLSFGHEAKGVMTTLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGVGILAGGFVALAVSSIFDKKFPAPTYAVNRALSTPPQVDYIWRIIVMFGALPAALTYYWRMKMPETARYTALVAKNIKQATADMSKVLQTDIELEERVEDDVKDPKQNYGLFSKEFLRRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPKAATMNATHEVFRIARAQTLIALCSTVPGYWFTVAFIDTIGRFKIQLNGFFMMTVFMFAIAFPYNHWIKPENRIGFVVMYSLTFFFANFGPNATTFIVPAEIFPARLRSTCHGISAAAGKAGAIVGAFGFLYAAQSQDKAKVDAGYPPGIGVKNSLIMLGVLNFIGMLFTFLVPEPKGKSLEELSGEAEVSHDEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
263	Phosphorylation	DMSKVLQTDIELEER CHHHHHHHHHCHHHH	34.48	23110452
509	Phosphorylation	VPEPKGKSLEELSGE CCCCCCCCHHHHCCC	50.08	23110452
514	Phosphorylation	GKSLEELSGEAEVSH CCCHHHHCCCCCCCC	37.56	19880383
520	Phosphorylation	LSGEAEVSHDEK--- HCCCCCCCCCCC---	19.41	20374526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHT11_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHT11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHT11_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHT11_ARATH	PHT1;1	physical	25754174
PHT14_ARATH	PHT1;4	physical	25754174

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Novel subsets of the Arabidopsis plasmalemma phosphoproteome identifyphosphorylation sites in secondary active transporters.";
Hem S., Rofidal V., Sommerer N., Rossignol M.;
Biochem. Biophys. Res. Commun. 363:375-380(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, AND MASSSPECTROMETRY.
PubMed: 17869214