PDFR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDFR_DROME
• UniProt AC: Q9W4Y2
• Protein Name: PDF receptor
• Gene Name: Pdfr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 669
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for PDF, a neuropeptide controlling circadian behavioral rhythms. Probably regulates circadian behavioral rhythms through coordination of activities of clock neurons. PDF-binding results in the elevation of cAMP synthesis..
• Protein Sequence: MTLLSNILDCGGCISAQRFTRLLRQSGSSGPSPSAPTAGTFESKSMLEPTSSHSLATGRVPLLHDFDASTTESPGTYVLDGVARVAQLALEPTVMDALPDSDTEQVLGNLNSSAPWNLTLASAAATNFENCSALFVNYTLPQTGLYCNWTWDTLLCWPPTPAGVLARMNCPGGFHGVDTRKFAIRKCELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSLFALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENTPYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARCTVMYMDTSLGECLWNYNLTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKLRQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTATNFAVWSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMYSGAYNTAPDTDAVQPAGDPSATGKRISPPNKRLNGRKPSSASIVMIHEPQQRQRLMPRLQNKAREKGKDRVEKTDAEAEPDPTISHIHSKEAGSARSRTRGSKWIMGICFRGQKVLRVPSASSVPPESVVFELSEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	N-linked_Glycosylation	EQVLGNLNSSAPWNL HHHHHCCCCCCCCHH	37.61	-
117	N-linked_Glycosylation	LNSSAPWNLTLASAA CCCCCCCHHHHHHHH	23.30	-
130	N-linked_Glycosylation	AAATNFENCSALFVN HHCCCCCCCEEEEEE	22.39	-
137	N-linked_Glycosylation	NCSALFVNYTLPQTG CCEEEEEEEECCCCC	19.41	-
148	N-linked_Glycosylation	PQTGLYCNWTWDTLL CCCCCCCCCEEEEEE	26.17	-
198	N-linked_Glycosylation	GRWGSRPNATEVNPP CCCCCCCCCCCCCCC	59.38	-
308	N-linked_Glycosylation	GNKEAATNTSLSVIE CCCCCCCCCCCHHHC	23.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDFR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDFR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDFR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDF_DROME	Pdf	genetic	16242402
DCO_DROME	dco	genetic	24820422

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.