PATL4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PATL4_ARATH
• UniProt AC: Q94C59
• Protein Name: Patellin-4
• Gene Name: PATL4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 540
• Subcellular Localization: Membrane; Peripheral membrane protein. Cytoplasm. Mainly membrane-associated. Also cytoplasmic (By similarity)..
• Protein Description: Carrier protein that may be involved in membrane-trafficking events associated with cell plate formation during cytokinesis. Binds to some hydrophobic molecules such as phosphoinositides and promotes their transfer between the different cellular sites (By similarity)..
• Protein Sequence: MTAEVKVEEKQVESEVVIAPAVVPEETTVKAVVEETKVEEDESKPEGVEKSASFKEESDFFADLKESEKKALSDLKSKLEEAIVDNTLLKTKKKESSPMKEKKEEVVKPEAEVEKKKEEAAEEKVEEEKKSEAVVTEEAPKAETVEAVVTEEIIPKEEVTTVVEKVEEETKEEEKKTEDVVTEEVKAETIEVEDEDESVDKDIELWGVPLLPSKGAESTDVILLKFLRARDFKVNEAFEMLKKTLKWRKQNKIDSILGEEFGEDLATAAYMNGVDRESHPVCYNVHSEELYQTIGSEKNREKFLRWRFQLMEKGIQKLNLKPGGVTSLLQIHDLKNAPGVSRTEIWVGIKKVIETLQDNYPEFVSRNIFINVPFWFYAMRAVLSPFLTQRTKSKFVVARPAKVRETLLKYIPADELPVQYGGFKTVDDTEFSNETVSEVVVKPGSSETIEIPAPETEGTLVWDIAVLGWEVNYKEEFVPTEEGAYTVIVQKVKKMGANEGPIRNSFKNSQAGKIVLTVDNVSGKKKKVLYRYRTKTESSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	KPEGVEKSASFKEES CCCCCCCCHHHCHHH	18.68	23776212
53	Phosphorylation	EGVEKSASFKEESDF CCCCCCHHHCHHHCC	43.90	24601666
58	Phosphorylation	SASFKEESDFFADLK CHHHCHHHCCCHHHH	40.59	23776212
96	Phosphorylation	LKTKKKESSPMKEKK HHCCCCCCCCCHHHH	48.93	25561503
97	Phosphorylation	KTKKKESSPMKEKKE HCCCCCCCCCHHHHH	30.06	25561503
182	Phosphorylation	KKTEDVVTEEVKAET HCCCCCCCHHHEEEE	26.69	19880383
505	Phosphorylation	NEGPIRNSFKNSQAG CCCCCCHHCCCCCCC	27.96	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PATL4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PATL4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PATL4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMO3_ARATH	SUMO3	physical	20855607
SUMO1_ARATH	SUMO1	physical	20855607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.
PubMed: 19376835

"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.
PubMed: 18433157

"Quantitative phosphoproteomics of early elicitor signaling inArabidopsis.";
Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M.,Menke F.L.H.;
Mol. Cell. Proteomics 6:1198-1214(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.
PubMed: 17317660