P85A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P85A_RAT
• UniProt AC: Q63787
• Protein Name: Phosphatidylinositol 3-kinase regulatory subunit alpha
• Gene Name: Pik3r1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 724
• Protein Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)..
• Protein Sequence: MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDPPSVDLDVFDEHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISAEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNDTIKIFEEQCHPQERYSKDYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVDDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSAEGYQYR ------CCCCCCHHH	34.72	-
31	Phosphorylation	LHLGDILTVNKGSLV EEHHCEEEECCCCEE	23.51	-
152	Phosphorylation	ECSTLYRTQSSSNPA CCHHHEECCCCCCHH	21.17	30181290
154	Phosphorylation	STLYRTQSSSNPAEL HHHEECCCCCCHHHH	34.81	30181290
155	Phosphorylation	TLYRTQSSSNPAELR HHEECCCCCCHHHHH	25.07	30181290
156	Phosphorylation	LYRTQSSSNPAELRQ HEECCCCCCHHHHHH	52.67	30181290
279	Phosphorylation	LFRFPAASSDNTEHL HHHCCCCCCCCHHHH	40.09	-
416	Phosphorylation	RNESLAQYNPKLDVK CCCHHHHHCCCCCEE	28.02	-
426	Phosphorylation	KLDVKLLYPVSKYQQ CCCEEEEEECCHHCC	16.42	-
452	Phosphorylation	VGKKLHEYNTQFQEK HHHHHHHHHHHHHHH	16.86	-
467	Phosphorylation	SREYDRLYEEYTRTS HHHHHHHHHHHHHHH	13.96	22673903
470	Phosphorylation	YDRLYEEYTRTSQEI HHHHHHHHHHHHHHH	6.92	25575281
508	Phosphorylation	QERYSKDYIEKFKRE CHHCCHHHHHHHHHC	18.08	16565309
580	Phosphorylation	LRKTRDQYLMWLTQK HHHCHHHHHHHHHHH	11.65	27097102
608	Phosphorylation	ENTEDQYSLVDDDED CCCCCCCCCCCCCCC	19.11	14729945
633	Acetylation	VGSSNRNKAENLLRG CCCCCCHHHHHHHHC	54.57	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P85A_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
608	S	Phosphorylation	Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P85A_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THA_RAT	Thra	physical	16717100
IRS1_RAT	Irs1	physical	7539611
IRS1_RAT	Irs1	physical	9415395
IRS1_HUMAN	IRS1	physical	25667086

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.