OTU7B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTU7B_MOUSE
• UniProt AC: B2RUR8
• Protein Name: OTU domain-containing protein 7B
• Gene Name: Otud7b
• Organism: Mus musculus (Mouse).
• Sequence Length: 840
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner.
• Protein Description: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. [PubMed: 23334419 Negatively regulates mucosal immunity against infections]
• Protein Sequence: MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDVIQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSMDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALRRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGSNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKESAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASIILSLEVKLHLLHSYMNVKWIPLSSDSQAPLAQPESPTASAGDEPRSTPESGESDKESVGSSSLGNEGSRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNTLKSWKGGKEEAAGDGPVSEKPPSESVGNGGSKYSQEVMQSLSTMRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQKEVERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPAEPKAMAFSTAYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPGRPYPHQDNIPALEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQTKCKQPNCSFYGHPETNNLCSCCYREELRRREREPGGELLAHRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	EGKNWDVSAALSDFE CCCCCCHHHHHCHHH		26745281
39	Phosphorylation	WDVSAALSDFEQLRQ CCHHHHHCHHHHHHH		26745281
53	Phosphorylation	QVHAGNLSPPFSGGS HHHCCCCCCCCCCCC		24453211
57	Phosphorylation	GNLSPPFSGGSTCPK CCCCCCCCCCCCCCC		25293948
60	Phosphorylation	SPPFSGGSTCPKTPE CCCCCCCCCCCCCCC		25293948
61	Phosphorylation	PPFSGGSTCPKTPEK CCCCCCCCCCCCCCC		25293948
65	Phosphorylation	GGSTCPKTPEKGGSD CCCCCCCCCCCCCCC		26643407
93	Ubiquitination	QDDVIQEKRLSRGIS CCHHHHHHHHHHHHC		22790023
96	Phosphorylation	VIQEKRLSRGISHAS HHHHHHHHHHHCHHH		26643407
100	Phosphorylation	KRLSRGISHASSSIV HHHHHHHCHHHHHHH		26824392
103	Phosphorylation	SRGISHASSSIVSLA HHHHCHHHHHHHHHH		28833060
104	Phosphorylation	RGISHASSSIVSLAR HHHCHHHHHHHHHHH		28833060
105	Phosphorylation	GISHASSSIVSLARS HHCHHHHHHHHHHHH		26060331
108	Phosphorylation	HASSSIVSLARSHVS HHHHHHHHHHHHHCC		28833060
171	Ubiquitination	LEQAGRLNWWVSMDS HHHHCCCCEEEECCC		27667366
218	Phosphorylation	LVLRKALYALMEKGV HHHHHHHHHHHHCCC		22817900
263	Ubiquitination	KEWNELIKLASSEPR HHHHHHHHHHHCCCC		22790023
437	Phosphorylation	NVKWIPLSSDSQAPL CCEEEECCCCCCCCC		25777480
438	Phosphorylation	VKWIPLSSDSQAPLA CEEEECCCCCCCCCC		25777480
440	Phosphorylation	WIPLSSDSQAPLAQP EEECCCCCCCCCCCC		25777480
449	Phosphorylation	APLAQPESPTASAGD CCCCCCCCCCCCCCC		27087446
451	Phosphorylation	LAQPESPTASAGDEP CCCCCCCCCCCCCCC		24453211
453	Phosphorylation	QPESPTASAGDEPRS CCCCCCCCCCCCCCC		24453211
460	Phosphorylation	SAGDEPRSTPESGES CCCCCCCCCCCCCCC		27087446
461	Phosphorylation	AGDEPRSTPESGESD CCCCCCCCCCCCCCC		29899451
464	Phosphorylation	EPRSTPESGESDKES CCCCCCCCCCCCHHC		27087446
467	O-linked_Glycosylation	STPESGESDKESVGS CCCCCCCCCHHCCCC		22645316
467	Phosphorylation	STPESGESDKESVGS CCCCCCCCCHHCCCC		25521595
471	Phosphorylation	SGESDKESVGSSSLG CCCCCHHCCCCCCCC		27742792
474	Phosphorylation	SDKESVGSSSLGNEG CCHHCCCCCCCCCHH		26239621
475	Phosphorylation	DKESVGSSSLGNEGS CHHCCCCCCCCCHHH		26239621
476	Phosphorylation	KESVGSSSLGNEGSR HHCCCCCCCCCHHHH		26239621
482	Phosphorylation	SSLGNEGSRRKEKSK CCCCCHHHHHHHHHH		23737553
501	Phosphorylation	KDKKRADSVANKLGS HHHHHHHHHHHHHHH		29514104
508	Phosphorylation	SVANKLGSFGKTLGS HHHHHHHHHHHHHHH		24453211
511	Ubiquitination	NKLGSFGKTLGSKLK HHHHHHHHHHHHHHH		22790023
539	Phosphorylation	PGGLGSGSGISSGTE CCCCCCCCCCCCCHH		26643407
542	Phosphorylation	LGSGSGISSGTETLE CCCCCCCCCCHHHHH		29550500
543	Phosphorylation	GSGSGISSGTETLEK CCCCCCCCCHHHHHH		26643407
545	Phosphorylation	GSGISSGTETLEKKK CCCCCCCHHHHHHHH		29550500
547	Phosphorylation	GISSGTETLEKKKKN CCCCCHHHHHHHHHC		26824392
589	Phosphorylation	VGNGGSKYSQEVMQS CCCCCCHHHHHHHHH		22817900
598	Phosphorylation	QEVMQSLSTMRIAMQ HHHHHHHCHHHHHCC		21183079
599	Phosphorylation	EVMQSLSTMRIAMQG HHHHHHCHHHHHCCC		21183079
610	Phosphorylation	AMQGEGKYIFVGTLK HCCCCCCEEEEEEEE		29514104
678	Phosphorylation	DGGEDQPSDSPAEPK CCCCCCCCCCCCCCC		23684622
680	Phosphorylation	GEDQPSDSPAEPKAM CCCCCCCCCCCCCCC		25521595
693	Phosphorylation	AMAFSTAYPGGFTIP CCEECCCCCCCEECC		29514104
698	Phosphorylation	TAYPGGFTIPRPSGG CCCCCCEECCCCCCC		26060331
727	Phosphorylation	PCVGGLPSYATFPRQ CCCCCCCCCCCCCCC		26239621
728	Phosphorylation	CVGGLPSYATFPRQY CCCCCCCCCCCCCCC		26239621
730	Phosphorylation	GGLPSYATFPRQYPG CCCCCCCCCCCCCCC		26239621
735	Phosphorylation	YATFPRQYPGRPYPH CCCCCCCCCCCCCCC		29514104
740	Phosphorylation	RQYPGRPYPHQDNIP CCCCCCCCCCCCCCC		29514104
772	Phosphorylation	QFRVADSYSNGYREP CCEECCCCCCCCCCC		29514104
776	Phosphorylation	ADSYSNGYREPPEPD CCCCCCCCCCCCCCC		29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTU7B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTU7B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTU7B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF3_MOUSE	Traf3	physical	23334419
APC_HUMAN	APC	physical	18281465

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.