OTU6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OTU6A_HUMAN
• UniProt AC: Q7L8S5
• Protein Name: OTU domain-containing protein 6A
• Gene Name: OTUD6A
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Protein Description: Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains..
• Protein Sequence: MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHRQELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEHLAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLVFSVSVEMLRCRTASYMKKHVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADSPTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	O-linked_Glycosylation	QIRSLKNSVPKTDKT HHHHHHHCCCCCCHH	37.90	30379171
71	Phosphorylation	EKFQDDSSIESVVED HHHCCCCCHHHHHHH	37.05	18452278
74	Phosphorylation	QDDSSIESVVEDLAK CCCCCHHHHHHHHHH	29.77	18452278
213	Phosphorylation	YCDNIVRTTAWGGQL EECCCCCCCCCCCHH	15.24	-
214	Phosphorylation	CDNIVRTTAWGGQLE ECCCCCCCCCCCHHH	15.17	-
249	Phosphorylation	TLIIGEEYVKKPIIL EEEECHHHCCCCEEH	17.17	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OTU6A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OTU6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OTU6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING2_HUMAN	RNF2	physical	23105109
HOIL1_HUMAN	RBCK1	physical	23105109
CBLC_HUMAN	CBLC	physical	23105109
TRI39_HUMAN	TRIM39	physical	23105109
TRI46_HUMAN	TRIM46	physical	23105109
TRIM5_HUMAN	TRIM5	physical	23105109
UBC_HUMAN	UBC	physical	23827681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.