OPRX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OPRX_HUMAN
• UniProt AC: P41146
• Protein Name: Nociceptin receptor
• Gene Name: OPRL1
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at
• Protein Description: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin..
• Protein Sequence: MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	N-linked_Glycosylation	YGSHLQGNLSLLSPN HCCCCCCCCCCCCCC	17.31	UniProtKB CARBOHYD
28	N-linked_Glycosylation	NLSLLSPNHSLLPPH CCCCCCCCCCCCCHH	33.72	UniProtKB CARBOHYD
39	N-linked_Glycosylation	LPPHLLLNASHGAFL CCHHHHHHCCCCCCC	39.09	UniProtKB CARBOHYD
164	Phosphorylation	RALDVRTSSKAQAVN HHHCCCCCCHHHHHH	21.19	24719451
165	Phosphorylation	ALDVRTSSKAQAVNV HHCCCCCCHHHHHHH	31.25	24719451
334	S-palmitoylation	KACFRKFCCASALRR HHHHHHHHHHHHHHH	1.81	-
346	Phosphorylation	LRRDVQVSDRVRSIA HHHCCCHHHHHHHHH	11.56	-
351	Phosphorylation	QVSDRVRSIAKDVAL CHHHHHHHHHHHHHH	24.84	-
362	Phosphorylation	DVALACKTSETVPRP HHHHHCCCCCCCCCC	31.51	25072903
363	Phosphorylation	VALACKTSETVPRPA HHHHCCCCCCCCCCC	19.43	22596163
365	Phosphorylation	LACKTSETVPRPA-- HHCCCCCCCCCCC--	35.26	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
346	S	Phosphorylation	Kinase	GRK2	P25098	PSP
346	S	Phosphorylation	Kinase	GRK3	P35626	PSP
351	S	Phosphorylation	Kinase	GRK2	P25098	PSP
351	S	Phosphorylation	Kinase	GRK3	P35626	PSP
362	T	Phosphorylation	Kinase	GRK2	P25098	PSP
362	T	Phosphorylation	Kinase	GRK3	P35626	PSP
363	S	Phosphorylation	Kinase	GRK2	P25098	PSP
363	S	Phosphorylation	Kinase	GRK3	P35626	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
363	S	Phosphorylation	Phosphorylation at Ser-363 requires GRK3.	23086955

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OPRX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PNOC_HUMAN	PNOC	physical	10692489
PNOC_HUMAN	PNOC	physical	11097863
GASP1_HUMAN	GPRASP1	physical	15086532

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.