OPN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OPN3_HUMAN
• UniProt AC: Q9H1Y3
• Protein Name: Opsin-3
• Gene Name: OPN3
• Organism: Homo sapiens (Human).
• Sequence Length: 402
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: May play a role in encephalic photoreception..
• Protein Sequence: MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MYSGNRSGG ------CCCCCCCCC	25.86	25954137
3	Phosphorylation	-----MYSGNRSGGH -----CCCCCCCCCC	28.44	25954137
5	N-linked_Glycosylation	---MYSGNRSGGHGY ---CCCCCCCCCCCC	29.07	UniProtKB CARBOHYD
7	Phosphorylation	-MYSGNRSGGHGYWD -CCCCCCCCCCCCCC	53.80	25954137
29	O-linked_Glycosylation	EGPAPAGTLSPAPLF CCCCCCCCCCCCCCC	26.60	OGP
31	Phosphorylation	PAPAGTLSPAPLFSP CCCCCCCCCCCCCCC	20.89	25954137
37	Phosphorylation	LSPAPLFSPGTYERL CCCCCCCCCCHHHHH	30.06	25954137
40	Phosphorylation	APLFSPGTYERLALL CCCCCCCHHHHHHHH	26.12	25954137
140	Phosphorylation	TVLAYERYIRVVHAR HHHHHHHHHHHHHHE	4.91	-
198	N-linked_Glycosylation	DWKSKDANDSSFVLF ECCCCCCCCCHHHHH	60.89	UniProtKB CARBOHYD
228	Phosphorylation	CYGHILYSIRMLRCV HHHHHHHHHHHHHHH	10.56	24719451
299	Other	IVSYLFAKSNTVYNP HHHHHHHCCCCCCCC	36.58	-
300	Phosphorylation	VSYLFAKSNTVYNPV HHHHHHCCCCCCCCH	34.01	23663014
302	Phosphorylation	YLFAKSNTVYNPVIY HHHHCCCCCCCCHHH	31.30	23663014
304	Phosphorylation	FAKSNTVYNPVIYVF HHCCCCCCCCHHHHH	16.23	23663014
309	Phosphorylation	TVYNPVIYVFMIRKF CCCCCHHHHHHHHHH	6.46	23663014
325	S-palmitoylation	RSLLQLLCLRLLRCQ HHHHHHHHHHHHHCC	2.56	-
343	Phosphorylation	KDLPAAGSEMQIRPI CCCCCCCCCCEEEEE	25.76	28348404
355	Ubiquitination	RPIVMSQKDGDRPKK EEEEECCCCCCCCCC	57.27	29967540
380	Phosphorylation	FIITSDESLSVDDSD EEEECCCCCCCCCCC	30.82	-
393	Ubiquitination	SDKTNGSKVDVIQVR CCCCCCCEEEEEEEE	43.80	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OPN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OPN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OPN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EI2BE_HUMAN	EIF2B5	physical	26186194
EI2BD_HUMAN	EIF2B4	physical	26186194
EI2BB_HUMAN	EIF2B2	physical	26186194
EI2BG_HUMAN	EIF2B3	physical	26186194
EI2BG_HUMAN	EIF2B3	physical	28514442
EI2BB_HUMAN	EIF2B2	physical	28514442
EI2BD_HUMAN	EIF2B4	physical	28514442
EI2BE_HUMAN	EIF2B5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.