OD3L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OD3L2_HUMAN
• UniProt AC: Q3SX64
• Protein Name: Outer dense fiber protein 3-like protein 2
• Gene Name: ODF3L2
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Protein Sequence: MGTLSCDSTPRLATAPLGRRVTEGQIPETGLRKSCGTATLENGSGPGLYVLPSTVGFINHDCTRVASPAYSLVRRPSEAPPQDTSPGPIYFLDPKVTRFGRSCTPAYSMQGRAKSRGPEVTPGPGAYSPEKVPPVRHRTPPAFTLGCRLPLKPLDTSAPAPNAYTMPPLWGSQIFTKPSSPSYTVVGRTPPARPPQDPAEIPGPGQYDSPDANTYRQRLPAFTMLGRPRAPRPLEETPGPGAHCPEQVTVNKARAPAFSMGIRHSKRASTMAATTPSRPAGHRLPGRCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	NGSGPGLYVLPSTVG CCCCCCEEECCCCCE	13.07	22817900
67	Phosphorylation	HDCTRVASPAYSLVR CCCCCCCCCHHHHHC	13.75	-
70	Phosphorylation	TRVASPAYSLVRRPS CCCCCCHHHHHCCCC	13.11	22817900
71	Phosphorylation	RVASPAYSLVRRPSE CCCCCHHHHHCCCCC	23.61	24719451
77	Phosphorylation	YSLVRRPSEAPPQDT HHHHCCCCCCCCCCC	44.58	25693802
85	Phosphorylation	EAPPQDTSPGPIYFL CCCCCCCCCCCEEEC	35.83	-
90	Phosphorylation	DTSPGPIYFLDPKVT CCCCCCEEECCCCCC	10.96	22817900
107	Phosphorylation	GRSCTPAYSMQGRAK CCCCCCCHHHCCCCH	13.09	22817900
115	Phosphorylation	SMQGRAKSRGPEVTP HHCCCCHHCCCCCCC	41.29	20068231
121	Phosphorylation	KSRGPEVTPGPGAYS HHCCCCCCCCCCCCC	22.36	20068231
127	Phosphorylation	VTPGPGAYSPEKVPP CCCCCCCCCCCCCCC	30.58	20068231
128	Phosphorylation	TPGPGAYSPEKVPPV CCCCCCCCCCCCCCC	26.50	20068231
207	Phosphorylation	EIPGPGQYDSPDANT CCCCCCCCCCCCHHH	25.05	22817900
215	Phosphorylation	DSPDANTYRQRLPAF CCCCHHHHHHHCCCH	12.45	22817900
265	Phosphorylation	FSMGIRHSKRASTMA HHCCCCCCHHHCCCC	17.62	20068231
267	Methylation	MGIRHSKRASTMAAT CCCCCCHHHCCCCCC	36.46	115368159
269	Phosphorylation	IRHSKRASTMAATTP CCCCHHHCCCCCCCC	23.81	20068231
270	Phosphorylation	RHSKRASTMAATTPS CCCHHHCCCCCCCCC	15.16	20068231
274	Phosphorylation	RASTMAATTPSRPAG HHCCCCCCCCCCCCC	29.69	20068231
278	Methylation	MAATTPSRPAGHRLP CCCCCCCCCCCCCCC	26.70	115368165
283	Methylation	PSRPAGHRLPGRCC- CCCCCCCCCCCCCC-	41.48	115368169

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OD3L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OD3L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OD3L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	18271526
NMT1_HUMAN	NMT1	physical	26186194
NMT2_HUMAN	NMT2	physical	26186194
GEPH_HUMAN	GPHN	physical	26186194
TPPC9_HUMAN	TRAPPC9	physical	26186194
FBXW5_HUMAN	FBXW5	physical	26186194
ABI1_HUMAN	ABI1	physical	26186194
GEPH_HUMAN	GPHN	physical	28514442
NMT2_HUMAN	NMT2	physical	28514442
FBXW5_HUMAN	FBXW5	physical	28514442
NMT1_HUMAN	NMT1	physical	28514442
BACD3_HUMAN	KCTD10	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-90 AND TYR-107, AND MASSSPECTROMETRY.
PubMed: 18083107