NXF1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXF1_DROME
• UniProt AC: Q9U1H9
• Protein Name: Nuclear RNA export factor 1
• Gene Name: sbr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 672
• Subcellular Localization: Nucleus, nucleoplasm . Cytoplasm . Nucleus envelope . Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.
• Protein Description: Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm..
• Protein Sequence: MPKRGGGSSQRYNNNVGNGGGRYNAPEDFDDFDVEDRQRRKDRNKRRVSFKPSQCLHNKKDIKLRPEDLRRWDEDDDMSDMTTAVKDRPTSRRRGSPIPRGKFGKLMPNSFGWYQVTLQNAQIYEKETLLSALLAAMSPHVFIPQYWRVERNCVIFFTDDYEAAERIQHLGKNGHLPDGYRLMPRVRSGIPLVAIDDAFKEKMKVTMAKRYNIQTKALDLSRFHADPDLKQVFCPLFRQNVMGAAIDIMCDNIPDLEALNLNDNSISSMEAFKGVEKRLPNLKILYLGDNKIPSLAHLVVLRNLSILELVLKNNPCRSRYKDSQQFISEVRRKFPKLVKLDGETLEPQITFDLSEQGRLLETKASYLCDVAGAEVVRQFLDQYFRIFDSGNRQALLDAYHEKAMLSISMPSASQAGRLNSFWKFNRNLRRLLNGEENRTRNLKYGRLACVSTLDEWPKTQHDRRTFTVDLTIYNTSMMVFTVTGLFKELNDETNNPASMELYDVRHFARTYVVVPQNNGFCIRNETIFITNATHEQVREFKRSQHQPAPGAMPSTSSAVTSPQAGAAAGLQGRLNALGVATGPVAILSGDPLAATAPVNSGSAAISTTAVAPGAQDESTKMQMIEAMSAQSQMNVIWSRKCLEETNWDFNHAAFVFEKLFKENKIPPEAFMK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Acetylation	NKRRVSFKPSQCLHN CCCCCCCCHHHHHCC	35.93	21791702
79	Phosphorylation	WDEDDDMSDMTTAVK CCCCCCHHHCCHHHH	31.09	19429919
82	Phosphorylation	DDDMSDMTTAVKDRP CCCHHHCCHHHHCCC	19.32	19429919
83	Phosphorylation	DDMSDMTTAVKDRPT CCHHHCCHHHHCCCC	23.86	19429919
96	Phosphorylation	PTSRRRGSPIPRGKF CCCCCCCCCCCCCCC	20.18	22817900
560	Phosphorylation	PSTSSAVTSPQAGAA CCCCCCCCCCCHHHH	34.11	30478224
561	Phosphorylation	STSSAVTSPQAGAAA CCCCCCCCCCHHHHH	14.39	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXF1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAGP1_DROME	RanGAP	physical	22036573
NXT1_DROME	Nxt1	physical	22036573
IMB1_HUMAN	KPNB1	physical	21965294
IPO11_HUMAN	IPO11	physical	21965294
IMPA1_HUMAN	IMPA1	physical	21965294

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, AND MASSSPECTROMETRY.
PubMed: 18327897