NUP98_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP98_CAEEL
• UniProt AC: G5EEH9
• Protein Name: Nuclear pore complex protein Nup98-Nup96 {ECO:0000250|UniProtKB:P52948}
• Gene Name: npp-10 {ECO:0000312|WormBase:ZK328.5b}
• Organism: Caenorhabditis elegans.
• Sequence Length: 1678
• Subcellular Localization: Nuclear pore complex protein Nup98: Cytoplasmic granule . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . P granule localization dependent on nucleoporins npp-7, npp-8 and npp-9 which are involved in P granule integrity.; Nuclea
• Protein Description: Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). [PubMed: 20335358]
• Protein Sequence: MFGQNKSFGSSSFGGGSSGSGLFGQNNQNNQNKGLFGQPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGSPQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFGASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTGTTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNANTSAASGSLFGAKPAGSSLFGSTATTGASTFGQTTGSSLFGNQQPQTNTGGSLFGNTQNQNQSGSLFGNTGTTGTGLFGQAQQQPQQQSSGFSFGGAPAATNAFGQPAAANTGGSLFGNTSTANTGSSLFGAKPATSTGFTFGATQPTTTNAFGSTNTGGGLFGNNAAKPGGLFGNTTNTGTGGGLFGSQPQASSGGLFGSNTQATQPLNTGFGNLAQPQIVMQQQVAPVPVIGVTADVLQMQANMKSLKSQLTNAPYGDSPLLKYNANPEIDGKSSPASTQRQLRFLAAKKGALSSSSDAQDSSFIIPPISKVMSDLSPAVTRSADVTKDLNYTSKEAPPSLARGLRNSTFNPNMSLTNRSVHESSALDKTIDSALDASMNGTSNRLGVRGSVRRSNLKQLDMSLLADSSRVGRESRVADPDALPRISESERRQDVVTSTPAVDPVQAVIQRHNDRNRDPPSLNLDTTCDEHTGLEPVSAATSSAASVVSTPSEETVNVNSAAGVKLTKPDYFSLPTINEMKNMIKNGRVVLEDGLTVGRSSYGSVYWPGRVELKDVALDEIVVFRHREVTVYPNEEEKAPEGQELNRPAEVTLERVWYTDKKTKKEVRDVVKLSEIGWREHLERQTIRMGAAFKDFRAETGSWVFRVDHFSKYGLADDDEPMDGSPPQQALQASSPLQVIDMNTSARDVNNQVQRKKVHKATDAHHQEIILERVPAPAALGDVVPIIRRVNRKGLGGGTLDDSREESCIGNMTTEFNESGHDSIIEEGQQPEKKPKLELLADLEYESSRFIRNLQELKVMPKANDPAHRFHGGGHSAKMIGYGKSKLIDIGIVKGRSSHVGWSETGCLVWSAQPRHNQVLFGTIDRTSDVNENTLISMLDVNVHVSETSRKGPSSQSNSVKSSLTSNFVTYSDSYSSMFAKYIDVAQAGGYDGHVSVWKLISALFPYERREGWSFERGEEIGEWLRTEAVKSVPDDRSADTSSNGVWNQLCLGDIDKAFQIAIDNNQPQLATMLQTSAVCPEATVHCFKAQLDNWKKCETLHLIPKETLKCYVLMSGLSHYEWDQDGKNHSINCLDGLNWIQALGLHVWYLRAWTGLEESYDAYQKDVNAGRAASNRGDLPGELIKLACESQHSVEVVLDCAAGENPNDYFLQWHVWSLLYSVGYRTMSKTSETRLHRNYSSQLEASSLSKYALFVLQHIDDDEERSTAVRSLLDRIARFTDNDMFDSISEQFDIPSEWIADAQFSIAKSVDDSTQLFELAVAAKNYLEICRLFVDDIAPTAVVAGDHDALKAACAMVRPFENQIPEWGATGMVYTDYCRLINLIENDAEEELLQDVLESLETRLHAPTISKNSLQKLSLQTIGRVLFEYRADKNTLPEWTKLLGHRQMFKIFRDRSSWGIERFTIEFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
543	Phosphorylation	NPEIDGKSSPASTQR CCCCCCCCCCHHHHH	47.27	19060867
544	Phosphorylation	PEIDGKSSPASTQRQ CCCCCCCCCHHHHHH	28.15	19060867
547	Phosphorylation	DGKSSPASTQRQLRF CCCCCCHHHHHHHHH	28.58	30078680
548	Phosphorylation	GKSSPASTQRQLRFL CCCCCHHHHHHHHHH	29.85	30078680
565	Phosphorylation	KKGALSSSSDAQDSS HCCCCCCCCCCCCCC	28.94	30078680
571	Phosphorylation	SSSDAQDSSFIIPPI CCCCCCCCCCCCCCH	18.31	30078680
572	Phosphorylation	SSDAQDSSFIIPPIS CCCCCCCCCCCCCHH	28.84	30078680
586	Phosphorylation	SKVMSDLSPAVTRSA HHHHHHCCCCHHHCC	18.79	28854356
696	Phosphorylation	PDALPRISESERRQD CCCCCCCCHHHHHCC	36.03	28854356
698	Phosphorylation	ALPRISESERRQDVV CCCCCCHHHHHCCCC	29.61	19530675
934	Phosphorylation	DDEPMDGSPPQQALQ CCCCCCCCCHHHHHH	29.19	28854356
943	Phosphorylation	PQQALQASSPLQVID HHHHHHCCCCCEEEE	21.37	30078680
944	Phosphorylation	QQALQASSPLQVIDM HHHHHCCCCCEEEEC	32.42	30078680
953	Phosphorylation	LQVIDMNTSARDVNN CEEEECCCCHHHHHH	19.68	30078680
954	Phosphorylation	QVIDMNTSARDVNNQ EEEECCCCHHHHHHH	19.12	30078680
1012	Phosphorylation	GGGTLDDSREESCIG CCCCCCCCCCCCCCC	41.06	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUP98_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP98_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP98_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMN1_CAEEL	lmn-1	physical	18692475
SAS4_CAEEL	sas-4	physical	18692475
DNJ10_CAEEL	dnj-10	physical	18692475
IFA4_CAEEL	ifa-4	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.