UniProt ID | NRP1_MOUSE | |
---|---|---|
UniProt AC | P97333 | |
Protein Name | Neuropilin-1 | |
Gene Name | Nrp1 | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 923 | |
Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
Protein Description | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. [PubMed: 26503042] | |
Protein Sequence | MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
150 | N-linked_Glycosylation | RGPECSQNYTAPTGV CCCCCCCCCCCCCCC | 21.59 | - | |
261 | N-linked_Glycosylation | AKEGFSANYSVLQSS HHCCCCCCHHHHHHH | 28.54 | 19656770 | |
300 | N-linked_Glycosylation | ASSQYGTNWSVERSR EECCCCCCCEEEECC | 25.35 | - | |
337 | Phosphorylation | LGLLRFVTAVGTQGA HHHHHHHHHHCCCCC | 16.95 | 22817900 | |
341 | Phosphorylation | RFVTAVGTQGAISKE HHHHHHCCCCCCCHH | 19.75 | 21183079 | |
349 | Phosphorylation | QGAISKETKKKYYVK CCCCCHHHHCCEEEE | 52.48 | 22817900 | |
377 | Ubiquitination | ISLKEGNKAIIFQGN EECEECCEEEEEECC | 52.39 | - | |
504 | Methylation | GVIIQGGKHRENKVF EEEEECCCCCCCCCE | 46.44 | - | |
522 | N-linked_Glycosylation | FKIAYSNNGSDWKTI EEEEECCCCCCCEEE | 45.46 | 19656770 | |
612 | O-linked_Glycosylation | DDQANCHSGTGDDFQ CCCCCCCCCCCCCEE | 40.00 | - | |
842 | N-linked_Glycosylation | GEGEGDKNISRKPGN CCCCCCCCCCCCCCC | 42.06 | - | |
894 | Phosphorylation | GMSERNLSALENYNF CCCHHCHHHHHHCCE | 34.06 | 25159016 | |
899 | Phosphorylation | NLSALENYNFELVDG CHHHHHHCCEEEECC | 16.32 | 29899451 | |
908 | Ubiquitination | FELVDGVKLKKDKLN EEEECCEEECCCCCC | 61.18 | 22790023 | |
913 | Ubiquitination | GVKLKKDKLNPQSNY CEEECCCCCCCCCCC | 60.07 | - | |
918 | Phosphorylation | KDKLNPQSNYSEA-- CCCCCCCCCCCCC-- | 38.70 | 22499769 | |
920 | Phosphorylation | KLNPQSNYSEA---- CCCCCCCCCCC---- | 17.09 | 20116462 | |
921 | Phosphorylation | LNPQSNYSEA----- CCCCCCCCCC----- | 31.16 | 22499769 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRP1_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRP1_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRP1_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SEM3F_HUMAN | SEMA3F | physical | 9331348 | |
SEM3A_MOUSE | Sema3a | physical | 23104057 | |
PLXA2_MOUSE | Plxna2 | physical | 23104057 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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N-linked Glycosylation | |
Reference | PubMed |
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation."; Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.; Mol. Cell. Proteomics 8:2555-2569(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-522, AND MASSSPECTROMETRY. |