NRP1_MOUSE - dbPTM
NRP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NRP1_MOUSE
UniProt AC P97333
Protein Name Neuropilin-1
Gene Name Nrp1
Organism Mus musculus (Mouse).
Sequence Length 923
Subcellular Localization Membrane
Single-pass type I membrane protein.
Protein Description Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. [PubMed: 26503042]
Protein Sequence MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
150N-linked_GlycosylationRGPECSQNYTAPTGV
CCCCCCCCCCCCCCC
21.59-
261N-linked_GlycosylationAKEGFSANYSVLQSS
HHCCCCCCHHHHHHH
28.5419656770
300N-linked_GlycosylationASSQYGTNWSVERSR
EECCCCCCCEEEECC
25.35-
337PhosphorylationLGLLRFVTAVGTQGA
HHHHHHHHHHCCCCC
16.9522817900
341PhosphorylationRFVTAVGTQGAISKE
HHHHHHCCCCCCCHH
19.7521183079
349PhosphorylationQGAISKETKKKYYVK
CCCCCHHHHCCEEEE
52.4822817900
377UbiquitinationISLKEGNKAIIFQGN
EECEECCEEEEEECC
52.39-
504MethylationGVIIQGGKHRENKVF
EEEEECCCCCCCCCE
46.44-
522N-linked_GlycosylationFKIAYSNNGSDWKTI
EEEEECCCCCCCEEE
45.4619656770
612O-linked_GlycosylationDDQANCHSGTGDDFQ
CCCCCCCCCCCCCEE
40.00-
842N-linked_GlycosylationGEGEGDKNISRKPGN
CCCCCCCCCCCCCCC
42.06-
894PhosphorylationGMSERNLSALENYNF
CCCHHCHHHHHHCCE
34.0625159016
899PhosphorylationNLSALENYNFELVDG
CHHHHHHCCEEEECC
16.3229899451
908UbiquitinationFELVDGVKLKKDKLN
EEEECCEEECCCCCC
61.1822790023
913UbiquitinationGVKLKKDKLNPQSNY
CEEECCCCCCCCCCC
60.07-
918PhosphorylationKDKLNPQSNYSEA--
CCCCCCCCCCCCC--
38.7022499769
920PhosphorylationKLNPQSNYSEA----
CCCCCCCCCCC----
17.0920116462
921PhosphorylationLNPQSNYSEA-----
CCCCCCCCCC-----
31.1622499769

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NRP1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NRP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NRP1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEM3F_HUMANSEMA3Fphysical
9331348
SEM3A_MOUSESema3aphysical
23104057
PLXA2_MOUSEPlxna2physical
23104057

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NRP1_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"The mouse C2C12 myoblast cell surface N-linked glycoproteome:identification, glycosite occupancy, and membrane orientation.";
Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I.,Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E.,Wollscheid B.;
Mol. Cell. Proteomics 8:2555-2569(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261 AND ASN-522, AND MASSSPECTROMETRY.

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