NR4A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR4A2_MOUSE
• UniProt AC: Q06219
• Protein Name: Nuclear receptor subfamily 4 group A member 2
• Gene Name: Nr4a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 598
• Subcellular Localization: Cytoplasm. Nucleus. Mostly nuclear; oxidative stress promotes cytoplasmic localization..
• Protein Description: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons..
• Protein Sequence: MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
126	Phosphorylation	SVYYKPSSPPTPSTP CCEECCCCCCCCCCC	43.35	-
129	Phosphorylation	YKPSSPPTPSTPSFQ ECCCCCCCCCCCCCE	33.00	-
132	Phosphorylation	SSPPTPSTPSFQVQH CCCCCCCCCCCEEEC	24.93	-
181	Phosphorylation	SLFSFKQSPPGTPVS EEEEECCCCCCCCCC	33.38	-
337	Phosphorylation	KEVVRTDSLKGRRGR EEEEECCCCCCCCCC	31.22	29176673
351	Phosphorylation	RLPSKPKSPQDPSPP CCCCCCCCCCCCCCC	36.00	22817900
356	Phosphorylation	PKSPQDPSPPSPPVS CCCCCCCCCCCCCHH	58.70	22817900
359	Phosphorylation	PQDPSPPSPPVSLIS CCCCCCCCCCHHHHH	45.26	30372032
363	Phosphorylation	SPPSPPVSLISALVR CCCCCCHHHHHHHHH	26.26	20415495
366	Phosphorylation	SPPVSLISALVRAHV CCCHHHHHHHHHHHC	22.35	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
126	S	Phosphorylation	Kinase	MAPK1	P63085	GPS
129	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
132	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
185	T	Phosphorylation	Kinase	MAPK1	P63085	GPS
347	S	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR4A2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR4A2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN1C_MOUSE	Cdkn1c	physical	14671317
K1522_HUMAN	KIAA1522	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.