dbPTM

NPLP1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NPLP1_DROME
UniProt AC	Q9W0W6
Protein Name	Neuropeptide-like 1
Gene Name	Nplp1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	309
Subcellular Localization	Secreted.
Protein Description	NPLP1-4: Acts as a ligand for the receptor-type guanylate cyclase Gyc76C. [PubMed: 21893139 Stimulates Gyc76c-dependent cGMP production and modulates the IMD innate immune pathway in response to salt stress by inducing nuclear translocation of NF-kappa-B protein Rel which leads to increased expression of the antimicrobial peptide diptericin]
Protein Sequence	MQAVLQSAHSSRRLMLLLSMLLNAAIQPRSIIVSATDDVANVSPCEMESLINQLMSPSPEYQLHASALRNQLKNLLRERQLAVGEEQPLGEYPDYLEEDKRSVAALAAQGLLNAPKRSLATLAKNGQLPTAEPGEDYGDADSGEPSEQKRYIGSLARAGGLMTYGKRNVGTLARDFQLPIPNGKRNIATMARLQSAPSTHRDPKRNVAAVARYNSQHGHIQRAGAEKRNLGALKSSPVHGVQQKREDEEMLLPAAAPDYADPMQSYWWYPSYAGYADLDWNDYRRAEKRFLGRVLPPTRATASTHRSRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	Phosphorylation	EDYGDADSGEPSEQK CCCCCCCCCCCCHHH	46.94	27794539
164	Tyrosine amide	RAGGLMTYGKRNVGT HHCCCCCCCCCCHHH	13.49	-
164	Amidation	RAGGLMTYGKRNVGT HHCCCCCCCCCCHHH	13.49	12171930
182	Asparagine amide	DFQLPIPNGKRNIAT HCCCCCCCCCCCHHH	70.14	-
182	Amidation	DFQLPIPNGKRNIAT HCCCCCCCCCCCHHH	70.14	12171930

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NPLP1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NPLP1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NPLP1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CNN_DROME	cnn	physical	14605208
MYSP1_DROME	Prm	physical	14605208
MYSP2_DROME	Prm	physical	14605208
TFP11_DROME	sip1	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NPLP1_DROME

Related Literatures of Post-Translational Modification