NMAH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMAH_SCHPO
• UniProt AC: Q9UT53
• Protein Name: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase {ECO:0000250|UniProtKB:Q06178}
• Gene Name: SPAC806.06c {ECO:0000312|PomBase:SPAC806.06c}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 368
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis..
• Protein Sequence: MHTMNGDNFANSFPKNPLLSRNSSSSNVIQYSDEFSPDEDWLNEHAAKEHEERIRRPSVNRAWQKNSTSGGPSVSLEKREADVASLGEVMDLEEVPRGITRQARQLNEYIFPKHRFRNHLVDEGKIPLVLVACGSFSPITYLHLRMFEMATDTIQEQTNMELVAGYFSPVNDHYKKEGLAPAYHRVRMCELACERTSSWLMVDAWESLQPSYTCTARVLDHFDEEINQKRGGITLSDGTKRPCKIMLLAGGDLIASMGEPGVWSDKDLHHILGKFGCCIVERTGSDVWAFLLAHDIMFAYRGNILVIKQLIYNDISSTKVRLFIRRGMSIRYLLPNSVIQYIERYALYRDAEPVKTIFYQSPFVRMEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	FPKNPLLSRNSSSSN CCCCCCCCCCCCCCC	36.78	24763107
23	Phosphorylation	NPLLSRNSSSSNVIQ CCCCCCCCCCCCEEE	30.41	21712547
24	Phosphorylation	PLLSRNSSSSNVIQY CCCCCCCCCCCEEEC	41.14	25720772
25	Phosphorylation	LLSRNSSSSNVIQYS CCCCCCCCCCEEECC	26.25	27738172
26	Phosphorylation	LSRNSSSSNVIQYSD CCCCCCCCCEEECCC	36.74	21712547
31	Phosphorylation	SSSNVIQYSDEFSPD CCCCEEECCCCCCCC	13.63	21712547
32	Phosphorylation	SSNVIQYSDEFSPDE CCCEEECCCCCCCCH	17.81	21712547
36	Phosphorylation	IQYSDEFSPDEDWLN EECCCCCCCCHHHHH	29.42	28889911
58	Phosphorylation	EERIRRPSVNRAWQK HHHHHCHHHHHHHHH	30.16	29996109
75	Phosphorylation	TSGGPSVSLEKREAD CCCCCCCCHHHHHHC	34.84	27738172
85	Phosphorylation	KREADVASLGEVMDL HHHHCCCHHHCCCCH	36.43	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMAH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMAH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMAH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMAH_SCHPO	SPAC806.06c	physical	23695164
NMAH_SCHPO	SPAC806.06c	physical	26771498
IMA2_SCHPO	imp1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36 AND SER-85, AND MASSSPECTROMETRY.
PubMed: 18257517