NLRX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRX1_MOUSE
• UniProt AC: Q3TL44
• Protein Name: NLR family member X1
• Gene Name: Nlrx1
• Organism: Mus musculus (Mouse).
• Sequence Length: 975
• Subcellular Localization: Mitochondrion outer membrane.
• Protein Description: Participates in antiviral signaling..
• Protein Sequence: MRWGCHLPRTSWGSGLGRTPQLPDEHISFLIQWSWPFKGVHPLRPPRAFIRYHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPSTELATGHQQTQAGLPPLALSQLFDPDSCGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRYTPLKEVLPLMTAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGPPAAIIVNLLRKYMLPEASILVTTRPSTISRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAGGASVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTHTSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTALQRVGKEVVEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPSEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGLLMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAAREHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSEVQRNVHSWDPLRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVEGEVKTLLEQLGGSGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	RHGQLFRSISATEAI CCHHHHHHHCHHHHH	17.35	30635358
74	Phosphorylation	GQLFRSISATEAIQR HHHHHHHCHHHHHHH	30.31	30635358
76	Phosphorylation	LFRSISATEAIQRHR HHHHHCHHHHHHHHH	21.11	30635358
428	Phosphorylation	LMSYAARTMGKLAYE HHHHHHHHHHHHHHC	26.08	28576409
644	S-nitrosocysteine	AVLAQLGCPIKNLDA HHHHHHCCCCCCHHH	4.24	-
644	S-nitrosylation	AVLAQLGCPIKNLDA HHHHHHCCCCCCHHH	4.24	21278135
659	Succinylation	LENAQAIKKKLGKLG HHHHHHHHHHHHHCC	47.04	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRX1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF6_MOUSE	Traf6	physical	21703539
NEMO_MOUSE	Ikbkg	physical	21703539
IKKA_MOUSE	Chuk	physical	21703539

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.