NGF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NGF_HUMAN
• UniProt AC: P01138
• Protein Name: Beta-nerve growth factor
• Gene Name: NGF
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Subcellular Localization: Secreted.
• Protein Description: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. [PubMed: 20164177]
• Protein Sequence: MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	O-linked_Glycosylation	HWTKLQHSLDTALRR HHHHHHHHHHHHHHH	18.25	55823607
46	O-linked_Glycosylation	KLQHSLDTALRRARS HHHHHHHHHHHHHHH	32.65	55823613
69	N-linked_Glycosylation	RVAGQTRNITVDPRL HHCCCCCCCCCCHHH	37.36	UniProtKB CARBOHYD
84	Phosphorylation	FKKRRLRSPRVLFST HHHCCCCCCCEEEEC	22.96	24719451
90	Phosphorylation	RSPRVLFSTQPPREA CCCCEEEECCCCCCC	23.21	24425749
100	Phosphorylation	PPREAADTQDLDFEV CCCCCCCCCCCCEEE	21.18	24425749
114	N-linked_Glycosylation	VGGAAPFNRTHRSKR ECCCCCCCCCCCCCC	47.05	UniProtKB CARBOHYD
155	Acetylation	TATDIKGKEVMVLGE CCCCCCCCEEEEEEE	41.98	19820847

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NGF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NGF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
84	Phosphorylation	80 (4)	R ⇒ Q	rs11466111	Diastolic blood pressure	28135244

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNR16_HUMAN	NGFR	physical	14985763
NTRK1_HUMAN	NTRK1	physical	14985763
NTRK1_HUMAN	NTRK1	physical	11729324
TNR16_HUMAN	NGFR	physical	11729324
TNR16_RAT	Ngfr	physical	18596692
NTRK1_HUMAN	NTRK1	physical	11738045

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608654: Neuropathy, hereditary sensory and autonomic, 5 (HSAN5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, AND MASSSPECTROMETRY.
PubMed: 17081983