| UniProt ID | NEGR1_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z3B1 | |
| Protein Name | Neuronal growth regulator 1 | |
| Gene Name | NEGR1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 354 | |
| Subcellular Localization |
Cell membrane Lipid-anchor, GPI-anchor. |
|
| Protein Description | May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).. | |
| Protein Sequence | MDMMLLVQGACCSNQWLAAVLLSLCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLEDGASKGAWLNRSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKPFENGQYLDIYGITRDQAGEYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 52 | Ubiquitination | VDNMMVRKGDTAVLR ECCEEEECCCEEEEE | 50.13 | 29967540 | |
| 55 | Phosphorylation | MMVRKGDTAVLRCYL EEEECCCEEEEEEEE | 27.60 | 24114839 | |
| 73 | N-linked_Glycosylation | ASKGAWLNRSSIIFA CCCCCEECCCEEEEE | 30.96 | UniProtKB CARBOHYD | |
| 98 | Ubiquitination | VSISTLNKRDYSLQI CEEECCCCCCCEEEE | 50.16 | 29967540 | |
| 122 | Phosphorylation | PYTCSVQTQHTPRTM CEEEEEECCCCCCEE | 21.84 | 24076635 | |
| 134 | Phosphorylation | RTMQVHLTVQVPPKI CEEEEEEEEECCCCE | 8.26 | 20068231 | |
| 142 | Phosphorylation | VQVPPKIYDISNDMT EECCCCEEEECCCEE | 17.22 | 24719451 | |
| 155 | N-linked_Glycosylation | MTVNEGTNVTLTCLA EEECCCCCEEEEEEE | 35.32 | UniProtKB CARBOHYD | |
| 163 | Phosphorylation | VTLTCLATGKPEPSI EEEEEEEECCCCCCC | 32.56 | 24719451 | |
| 171 | Phosphorylation | GKPEPSISWRHISPS CCCCCCCEEEECCCC | 23.54 | 24719451 | |
| 187 | Phosphorylation | KPFENGQYLDIYGIT CCCCCCCEEEEEEEE | 14.03 | 21082442 | |
| 231 | Ubiquitination | APTIQEIKSGTVTPG CCCEEHHHCCCCCCC | 41.92 | 29967540 | |
| 275 | N-linked_Glycosylation | QQGIIIQNFSTRSIL CCEEEEEECCCCCEE | 23.56 | UniProtKB CARBOHYD | |
| 277 | Phosphorylation | GIIIQNFSTRSILTV EEEEEECCCCCEEEE | 30.38 | 24076635 | |
| 286 | N-linked_Glycosylation | RSILTVTNVTQEHFG CCEEEEEECCHHHHC | 30.42 | UniProtKB CARBOHYD | |
| 294 | N-linked_Glycosylation | VTQEHFGNYTCVAAN CCHHHHCCEEEEEEC | 28.17 | UniProtKB CARBOHYD | |
| 307 | N-linked_Glycosylation | ANKLGTTNASLPLNP ECCCCCCCCCCCCCC | 27.63 | UniProtKB CARBOHYD | |
| 324 | GPI-anchor | TAQYGITGSADVLFS CHHCCCCCCHHHHHH | 20.93 | 16602701 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEGR1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEGR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEGR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| NTRI_HUMAN | NTM | physical | 21982860 | |
| NEGR1_HUMAN | NEGR1 | physical | 21982860 | |
| LSAMP_HUMAN | LSAMP | physical | 21982860 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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