NAC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAC1_MOUSE
• UniProt AC: P70414
• Protein Name: Sodium/calcium exchanger 1
• Gene Name: Slc8a1
• Organism: Mus musculus (Mouse).
• Sequence Length: 970
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. [PubMed: 8659820 Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline]
• Protein Sequence: MLRLSLPPNVSMGFRLVALVALLFSHVDHITADTEAETGGNETTECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMEMAENDPVSKIFFEQGTYQCLENCGTVALTIMRRGGDLSTTVFVDFRTEDGTANAASDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSDVSEDGILESNHASSIACLGSPSTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGEPEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTGKEMYGQPIFRKVHARDHPIPSTVITISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIQESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	TEAETGGNETTECTG CCCCCCCCCCEEECE	44.80	-
90	Phosphorylation	VYMFLGVSIIADRFM HHHHHHHHHHHHHHH	13.38	-
99	Phosphorylation	IADRFMSSIEVITSQ HHHHHHHCCEEEECC	15.81	22871156
119	Phosphorylation	IKKPNGETTKTTVRI EECCCCCCEEEEEEE	34.68	22871156
120	Phosphorylation	KKPNGETTKTTVRIW ECCCCCCEEEEEEEE	23.30	22871156
157	N-linked_Glycosylation	VIEVCGHNFTAGDLG HHHHCCCCCCCCCCC	22.65	-
257	Ubiquitination	DRRLLFYKYVYKRYR HHHHHHHHHHHHHHH	22.39	-
282	Phosphorylation	HEGDRPASKTEIEMD ECCCCCCCCCEEEEC	42.67	25521595
283	Ubiquitination	EGDRPASKTEIEMDG CCCCCCCCCEEEECC	52.89	-
284	Phosphorylation	GDRPASKTEIEMDGK CCCCCCCCEEEECCE	39.43	25521595
356	Ubiquitination	QVLSQQQKSRAFYRI HHHCHHHHCHHHHHH	37.26	-
377	Ubiquitination	TGAGNILKRHAADQA HCHHHHHHHHHHHHH	38.04	-
389	Phosphorylation	DQARKAVSMHEVNME HHHHHHHHHHHHCHH	21.20	26824392
572	Ubiquitination	GNVIIPYKTIEGTAR CCEEEEEEEECCCCC	37.36	-
606	Ubiquitination	IVKTISVKVIDDEEY EEEEEEEEECCHHHH	27.04	-
615	Ubiquitination	IDDEEYEKNKTFFIE CCHHHHHHCCEEEEE	63.94	-
632	Phosphorylation	EPRLVEMSEKKALLL CCEEEECHHHHCHHH	32.53	22817900
634	Ubiquitination	RLVEMSEKKALLLNE EEEECHHHHCHHHHH	35.72	-
646	Phosphorylation	LNELGGFTLTGKEMY HHHHCCEEECCHHHC	27.04	22817900
682	Ubiquitination	ISEEYDDKQPLTSKE ECCCCCCCCCCCCHH	51.41	-
686	Phosphorylation	YDDKQPLTSKEEEER CCCCCCCCCHHHHHH	44.42	26824392
687	Phosphorylation	DDKQPLTSKEEEERR CCCCCCCCHHHHHHH	45.83	26824392
717	Phosphorylation	EVIIQESYEFKSTVD EEEEECCCCCHHHHH	25.32	28494245
725	Ubiquitination	EFKSTVDKLIKKTNL CCHHHHHHHHHHCCE	48.01	-
729	Ubiquitination	TVDKLIKKTNLALVV HHHHHHHHCCEEEEE	35.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NAC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT1A1_MOUSE	Atp1a1	physical	15485817
AT1A2_MOUSE	Atp1a2	physical	15485817

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.