MTAL2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTAL2_YEAST
• UniProt AC: P0CY08
• Protein Name: Mating-type protein ALPHA2
• Gene Name: MATALPHA2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 210
• Subcellular Localization: Nucleus.
• Protein Description: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that binds cooperatively with MCM1 to a 31-basepair DNA sequence termed the a-specific gene (asg) operator, to repress the transcription of a-cell-specific genes. Additionally, in a/alpha diploid cells, binds cooperatively with the A1 protein to a 21-basepair DNA sequence termed the haploid-specific gene (hsg) operator, to repress transcription of haploid-specific genes and of MATALPHA1..
• Protein Sequence: MNKIPIKDLLNPQITDEFKSSILDINKKLFSICCNLPKLPESVTTEEEVELRDILGFLSRANKNRKISDEEKKLLQTTSQLTTTITVLLKEMRSIENDRSNYQLTQKNKSADGLVFNVVTQDMINKSTKPYRGHRFTKENVRILESWFAKNIENPYLDTKGLENLMKNTSLSRIQIKNWVSNRRRKEKTITIAPELADLLSGEPLAKKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNKIPIKD -------CCCCCHHH	11.84	20110468

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SSM4	P40318	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTAL2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTAL2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYC8_YEAST	CYC8	physical	10759558
TUP1_YEAST	TUP1	physical	9315661
HMRA1_YEAST	HMRA1	physical	7569974
ASG7_YEAST	ASG7	genetic	13680367
SST2_YEAST	SST2	genetic	13680367

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"N-terminal acetylation of cellular proteins creates specificdegradation signals.";
Hwang C.S., Shemorry A., Varshavsky A.;
Science 327:973-977(2010).
Cited for: PROTEIN SEQUENCE OF 1-7, AND ACETYLATION AT MET-1.
PubMed: 20110468