MRCKG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRCKG_HUMAN
• UniProt AC: Q6DT37
• Protein Name: Serine/threonine-protein kinase MRCK gamma
• Gene Name: CDC42BPG {ECO:0000312|HGNC:HGNC:29829}
• Organism: Homo sapiens (Human).
• Sequence Length: 1551
• Subcellular Localization: Cytoplasm . Concentrates at the leading edge of cells.
• Protein Description: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity)..
• Protein Sequence: MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	PGLDGLLDLLLALHH CCHHHHHHHHHHHHH	40.07	22817900
32	Ubiquitination	LLDLLLALHHELSSG HHHHHHHHHHHHCCC	4.23	24816145
46	Phosphorylation	GPLRRERSVAQFLSW CCCHHHHHHHHHHHH	19.63	30622161
52	Phosphorylation	RSVAQFLSWASPFVS HHHHHHHHHHCHHHH	23.14	30622161
55	Phosphorylation	AQFLSWASPFVSKVK HHHHHHHCHHHHHHH	16.77	30622161
59	Phosphorylation	SWASPFVSKVKELRL HHHCHHHHHHHHHHH	31.91	30622161
60	Acetylation	WASPFVSKVKELRLQ HHCHHHHHHHHHHHC	52.61	25953088
62	Acetylation	SPFVSKVKELRLQRD CHHHHHHHHHHHCCC	55.56	25953088
75	Ubiquitination	RDDFEILKVIGRGAF CCCCHHHHHHCCCCC	37.15	22817900
125	Ubiquitination	EERDVLVKGDSRWVT CCCCEEEECCCCEEE	53.49	22817900
158	Phosphorylation	YAGGDLLTLLSRFED HCCCCHHHHHHHHHH	32.71	22468782
205	Ubiquitination	PDNVLLDVNGHIRLA CCCEEEECCCCEEEC	10.49	27667366
216	Phosphorylation	IRLADFGSCLRLNTN EEECCCCCCEEECCC	15.24	-
222	Phosphorylation	GSCLRLNTNGMVDSS CCCEEECCCCCCCCE	37.43	-
228	Phosphorylation	NTNGMVDSSVAVGTP CCCCCCCCEEECCCC	18.46	-
234	Phosphorylation	DSSVAVGTPDYISPE CCEEECCCCCCCCHH	13.34	-
239	Phosphorylation	VGTPDYISPEILQAM CCCCCCCCHHHHHHH	15.39	-
480	Phosphorylation	TDGPPAGSPGQDSDL CCCCCCCCCCCCHHH	28.15	25849741
485	Phosphorylation	AGSPGQDSDLRQELD CCCCCCCHHHHHHHH	30.56	23898821
486	Ubiquitination	GSPGQDSDLRQELDR CCCCCCHHHHHHHHH	54.91	22817900
565	Ubiquitination	EAQVSSLSRQVTQLQ HHHHHHHHHHHHHHH	23.71	22817900
638	Ubiquitination	KEEALCQLQEENRRL HHHHHHHHHHHHHHH	7.26	24816145
646	Phosphorylation	QEENRRLSREQERLE HHHHHHHHHHHHHHH	31.77	23312004
656	Ubiquitination	QERLEAELAQEQESK HHHHHHHHHHHHHHH	8.42	22817900
662	Phosphorylation	ELAQEQESKQRLEGE HHHHHHHHHHHHHHH	33.51	23312004
663	Ubiquitination	LAQEQESKQRLEGER HHHHHHHHHHHHHHH	38.39	22817900
699	Ubiquitination	KVSRGYLQALATKMA HCCHHHHHHHHHHHH	26.33	22817900
717	Phosphorylation	ESLRNVGTQTLPARP HHHHCCCCCCCCCCC	17.69	26074081
719	Phosphorylation	LRNVGTQTLPARPLD HHCCCCCCCCCCCCC	34.25	26074081
729	Ubiquitination	ARPLDHQWKARRLQK CCCCCHHHHHHHHHH	7.89	24816145
736	Ubiquitination	WKARRLQKMEASARL HHHHHHHHHHHHHHH	43.21	24816145
740	Phosphorylation	RLQKMEASARLELQS HHHHHHHHHHHHHHH	10.70	-
747	Phosphorylation	SARLELQSALEAEIR HHHHHHHHHHHHHHH	47.66	-
784	Phosphorylation	LQEAEKQSQALQQEL HHHHHHHHHHHHHHH	28.61	22210691
811	Ubiquitination	VDTKPSNSLIPFLSF CCCCCCCCCCCCHHC	31.82	27667366
811	Phosphorylation	VDTKPSNSLIPFLSF CCCCCCCCCCCCHHC	31.82	28102081
817	Phosphorylation	NSLIPFLSFRSSEKD CCCCCCHHCCCCCCC	20.99	28102081
820	Phosphorylation	IPFLSFRSSEKDSAK CCCHHCCCCCCCCCC	40.62	28102081
821	Phosphorylation	PFLSFRSSEKDSAKD CCHHCCCCCCCCCCC	44.39	28102081
827	Ubiquitination	SSEKDSAKDPGISGE CCCCCCCCCCCCCCC	69.29	-
832	Phosphorylation	SAKDPGISGEATRHG CCCCCCCCCCHHCCC	36.17	22210691
836	Phosphorylation	PGISGEATRHGGEPD CCCCCCHHCCCCCCC	20.92	22210691
851	Phosphorylation	LRPEGRRSLRMGAVF CCCCCCHHCCCCCCC	20.97	-
866	Phosphorylation	PRAPTANTASTEGLP CCCCCCCCCCCCCCC	21.37	28348404
868	Phosphorylation	APTANTASTEGLPAK CCCCCCCCCCCCCCC	25.59	28348404
869	Phosphorylation	PTANTASTEGLPAKP CCCCCCCCCCCCCCC	31.44	28348404
875	Ubiquitination	STEGLPAKPGSHTLR CCCCCCCCCCCCCCC	48.23	27667366
885	Phosphorylation	SHTLRPRSFPSPTKC CCCCCCCCCCCCCHH	44.16	27499020
888	Phosphorylation	LRPRSFPSPTKCLRC CCCCCCCCCCHHHHH	43.10	24719451
890	Phosphorylation	PRSFPSPTKCLRCTS CCCCCCCCHHHHHHH	38.43	23312004
891	Ubiquitination	RSFPSPTKCLRCTSL CCCCCCCHHHHHHHH	34.36	27667366
896	Phosphorylation	PTKCLRCTSLMLGLG CCHHHHHHHHHHCCC	20.61	27251275
897	Phosphorylation	TKCLRCTSLMLGLGR CHHHHHHHHHHCCCC	18.53	27251275
902	Ubiquitination	CTSLMLGLGRQGLGC HHHHHHCCCCCCCCC	4.50	27667366
908	Ubiquitination	GLGRQGLGCDACGYF CCCCCCCCCCCCCCE	17.68	27667366
909	Ubiquitination	LGRQGLGCDACGYFC CCCCCCCCCCCCCEE	3.45	27667366
955	Phosphorylation	TAYEGFLSVPRPSGV CCEECEECCCCCCCC	28.02	24719451
989	Phosphorylation	DAPDLRLSPPSGALL ECCCCCCCCCCCCEE	28.47	23898821
1009	Phosphorylation	RDPQFSATPVLASDV CCCCCCCCCCHHHHH	16.84	23898821
1092	Ubiquitination	YDNGLPLLPHTLCAA HHCCCCCCCHHHHHH	2.49	22817900
1121	Phosphorylation	LFVIHLRSNDIFQVG EEEEEECCCCCEEEC	45.26	-
1172	Ubiquitination	NIEVAGAKIPESRGC CCEECCCCCCCCCCC	58.85	21906983
1183	Ubiquitination	SRGCQVLAAGSILQA CCCCCEEECCHHHHC	15.77	22817900
1189	Ubiquitination	LAAGSILQARTPVLC EECCHHHHCCCCEEE	27.42	22817900
1190	Ubiquitination	AAGSILQARTPVLCV ECCHHHHCCCCEEEE	17.54	22817900
1200	Methylation	PVLCVAVKRQVLCYQ CEEEEEEECCEEHHH	27.63	-
1305	Ubiquitination	GIYVDGAGRKSRGHE CEEECCCCCCCCCCC	42.98	22817900
1385	Ubiquitination	LRNQLAEKDEFDIPD HHHHHCCCCCCCCCC	57.88	22817900
1396	Ubiquitination	DIPDLTDNSRRQLFR CCCCCCCCHHHHHHH	31.98	22817900
1402	Ubiquitination	DNSRRQLFRTKSKRR CCHHHHHHHCCCHHH	7.64	22817900
1403	Ubiquitination	NSRRQLFRTKSKRRF CHHHHHHHCCCHHHH	50.24	22817900
1462	Phosphorylation	RPGARDKSPAPEEKG CCCCCCCCCCCHHCC	30.50	25849741
1473	Methylation	EEKGRVARGSGPQRP HHCCCCCCCCCCCCC	36.63	-
1475	Phosphorylation	KGRVARGSGPQRPHS CCCCCCCCCCCCCCC	41.57	23927012
1482	Phosphorylation	SGPQRPHSFSEALRR CCCCCCCCHHHHHHC	32.90	30278072
1484	Phosphorylation	PQRPHSFSEALRRPA CCCCCCHHHHHHCCH	25.60	23927012
1492	Phosphorylation	EALRRPASMGSEGLG HHHHCCHHCCCCCCC	26.76	23927012
1495	Phosphorylation	RRPASMGSEGLGGDA HCCHHCCCCCCCCCC	21.61	23927012
1511	Phosphorylation	PMKRKPWTSLSSESV CCCCCCCCCCCCCCC	28.46	27251275
1512	Phosphorylation	MKRKPWTSLSSESVS CCCCCCCCCCCCCCC	23.53	25841592
1514	Phosphorylation	RKPWTSLSSESVSCP CCCCCCCCCCCCCCC	31.65	26657352
1515	Phosphorylation	KPWTSLSSESVSCPQ CCCCCCCCCCCCCCC	38.90	25841592
1517	Phosphorylation	WTSLSSESVSCPQGS CCCCCCCCCCCCCCC	22.68	23898821
1519	Phosphorylation	SLSSESVSCPQGSLS CCCCCCCCCCCCCCC	29.38	25841592
1524	Phosphorylation	SVSCPQGSLSPATSL CCCCCCCCCCCCHHH	22.04	26657352
1526	Phosphorylation	SCPQGSLSPATSLMQ CCCCCCCCCCHHHHH	17.74	33259812
1529	Phosphorylation	QGSLSPATSLMQVSE CCCCCCCHHHHHCCC	26.27	27251275
1530	Phosphorylation	GSLSPATSLMQVSER CCCCCCHHHHHCCCC	24.77	27251275
1535	Phosphorylation	ATSLMQVSERPRSLP CHHHHHCCCCCCCCC	15.82	25841592
1540	Phosphorylation	QVSERPRSLPLSPEL HCCCCCCCCCCCHHH	36.70	30266825
1544	Phosphorylation	RPRSLPLSPELESSP CCCCCCCCHHHCCCC	17.87	30266825
1549	Phosphorylation	PLSPELESSP----- CCCHHHCCCC-----	61.61	30278072
1550	Phosphorylation	LSPELESSP------ CCHHHCCCC------	25.83	30278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRCKG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRCKG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRCKG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAC1_HUMAN	RAC1	physical	15194684
CDC42_HUMAN	CDC42	physical	15194684
RHOQ_HUMAN	RHOQ	physical	15194684

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1540, AND MASSSPECTROMETRY.
PubMed: 19369195

"Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1binding.";
Ng Y., Tan I., Lim L., Leung T.;
J. Biol. Chem. 279:34156-34164(2004).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUESPECIFICITY.
PubMed: 15194684