MND1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MND1_HUMAN
• UniProt AC: Q9BWT6
• Protein Name: Meiotic nuclear division protein 1 homolog
• Gene Name: MND1 {ECO:0000312|EMBL:EAX04964.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Subcellular Localization: Nucleus .
• Protein Description: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks..
• Protein Sequence: MSKKKGLSAEEKRTRMMEIFSETKDVFQLKDLEKIAPKEKGITAMSVKEVLQSLVDDGMVDCERIGTSNYYWAFPSKALHARKHKLEVLESQLSEGSQKHASLQKSIEKAKIGRCETEERTRLAKELSSLRDQREQLKAEVEKYKDCDPQVVEEIRQANKVAKEAANRWTDNIFAIKSWAKRKFGFEENKIDRTFGIPEDFDYID

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSKKKGLSA ------CCCCCCCCH	53.86	22814378
14	Phosphorylation	LSAEEKRTRMMEIFS CCHHHHHHHHHHHHH	33.70	29759185
30	Ubiquitination	TKDVFQLKDLEKIAP CCCCHHHCCHHHHCC	49.86	21890473
46	Phosphorylation	EKGITAMSVKEVLQS CCCCCCCCHHHHHHH	27.81	24719451
67	Phosphorylation	VDCERIGTSNYYWAF EEHHHCCCCCCEEEC	16.07	28796482
68	Phosphorylation	DCERIGTSNYYWAFP EHHHCCCCCCEEECC	20.02	28796482
70	Phosphorylation	ERIGTSNYYWAFPSK HHCCCCCCEEECCHH	10.51	28796482
71	Phosphorylation	RIGTSNYYWAFPSKA HCCCCCCEEECCHHH	8.43	28796482
77	Ubiquitination	YYWAFPSKALHARKH CEEECCHHHHHHHHH	56.03	-
77	Acetylation	YYWAFPSKALHARKH CEEECCHHHHHHHHH	56.03	26051181
102	Phosphorylation	EGSQKHASLQKSIEK HHHHHHHHHHHHHHH	30.93	26270265
105	Ubiquitination	QKHASLQKSIEKAKI HHHHHHHHHHHHHHC	59.71	-
106	Phosphorylation	KHASLQKSIEKAKIG HHHHHHHHHHHHHCC	24.02	26270265
121	O-linked_Glycosylation	RCETEERTRLAKELS CCCHHHHHHHHHHHH	33.06	30379171
125	Ubiquitination	EERTRLAKELSSLRD HHHHHHHHHHHHHHH	64.87	-
128	Phosphorylation	TRLAKELSSLRDQRE HHHHHHHHHHHHHHH	28.55	30301811
129	Phosphorylation	RLAKELSSLRDQREQ HHHHHHHHHHHHHHH	39.80	25954137
138	Ubiquitination	RDQREQLKAEVEKYK HHHHHHHHHHHHHHC	42.04	-
145	Acetylation	KAEVEKYKDCDPQVV HHHHHHHCCCCHHHH	64.05	26051181
177	Ubiquitination	TDNIFAIKSWAKRKF HHCCHHHHHHHHHHH	36.19	-
190	Ubiquitination	KFGFEENKIDRTFGI HHCCCCCCCCCCCCC	49.62	-
203	Phosphorylation	GIPEDFDYID----- CCCCCCCCCC-----	13.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MND1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MND1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MND1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HOP2_HUMAN	PSMC3IP	physical	26344197
RED_HUMAN	IK	physical	26496610
HOP2_HUMAN	PSMC3IP	physical	26496610
HOP2_HUMAN	PSMC3IP	physical	28514442
MTEF4_HUMAN	MTERF4	physical	28514442
NSUN4_HUMAN	NSUN4	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.