MF2L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MF2L2_HUMAN
• UniProt AC: Q86YR7
• Protein Name: Probable guanine nucleotide exchange factor MCF2L2
• Gene Name: MCF2L2
• Organism: Homo sapiens (Human).
• Sequence Length: 1114
• Protein Description: Probably functions as a guanine nucleotide exchange factor..
• Protein Sequence: MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFEDCEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTEEERAGASTGRLAPAGATAGFQARALRPRTSAQES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	ELTRRLATVITHVDE HHHHHHHHHHHHHHH	19.62	26657352
138	Phosphorylation	LIFILRPSRFIQRTF EEEEECHHHHHHHHH	33.13	24719451
255	Ubiquitination	DKLQDELKLLGKQGT HHHHHHHHHHCCCCC	39.35	29967540
426	Phosphorylation	KWDILGKSLEFHRQL HHCHHHHHHHHHHHH	31.19	-
435	Methylation	EFHRQLDKVSQWCEA HHHHHHHHHHHHHHH	52.99	-
435	Trimethylation	EFHRQLDKVSQWCEA HHHHHHHHHHHHHHH	52.99	-
437	Phosphorylation	HRQLDKVSQWCEAGI HHHHHHHHHHHHHHH	24.57	-
449	Phosphorylation	AGIYLLASQAVDKCQ HHHHHHHHHHHHHHH	20.74	-
482	Phosphorylation	VKEYPLLSPKEFYNE CCCCCCCCHHHHHCH	41.42	24719451
504	Ubiquitination	DAKAKAQKVLQRLDD CHHHHHHHHHHCHHH	50.18	29967540
531	Phosphorylation	MKLAAKQTRPVQPVA HHHHHCCCCCCCCCC	35.91	-
550	Phosphorylation	SSPKWVSSKTSQPST CCCCCCCCCCCCCCC	30.27	24719451
618	Phosphorylation	QARLGDLSPRRRIIR HHHHCCCCHHHHHHH	22.54	24719451
630	Phosphorylation	IIRDLLETEEIYIKE HHHHHHHCCCHHHHH	38.60	-
677	Phosphorylation	FGNIRELYEFHNRTF HCCHHHHHHHHCHHH	16.28	30576142
751	Phosphorylation	HNLPLFKYLKGPSQR CCCCHHHHCCCHHHH	13.30	-
762	Phosphorylation	PSQRLIKYQMLLKGL HHHHHHHHHHHHHHH	7.67	27251275
774	Phosphorylation	KGLLDFESPEDMEID HHHCCCCCCCCCCCC	33.32	27251275
900	Acetylation	LSPHYSFKKTMKLMT CCCCCCHHHHHHHHH	41.20	19657513
901	Acetylation	SPHYSFKKTMKLMTL CCCCCHHHHHHHHHH	52.41	19657509
904	Acetylation	YSFKKTMKLMTLSIR CCHHHHHHHHHHHHH	40.10	19820257
907	Phosphorylation	KKTMKLMTLSIRQLG HHHHHHHHHHHHHHC	27.99	24043423
909	Phosphorylation	TMKLMTLSIRQLGRG HHHHHHHHHHHHCCC	13.42	24719451
991	Phosphorylation	IKNMERATTSKEDPA HCCHHHHCCCCCCCC	37.51	29083192
992	Phosphorylation	KNMERATTSKEDPAS CCHHHHCCCCCCCCC	36.50	29083192
993	Phosphorylation	NMERATTSKEDPASS CHHHHCCCCCCCCCC	29.68	29083192
999	Phosphorylation	TSKEDPASSTGGIKG CCCCCCCCCCCCCCC	33.54	29083192
1000	Phosphorylation	SKEDPASSTGGIKGC CCCCCCCCCCCCCCC	32.93	29083192
1001	Phosphorylation	KEDPASSTGGIKGCS CCCCCCCCCCCCCCC	36.61	29083192
1017	Phosphorylation	REFSSMDTFEDCEGA CCCCCCCCHHCCCCC	21.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MF2L2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MF2L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MF2L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HIC2_HUMAN	HIC2	physical	28514442
CDK6_HUMAN	CDK6	physical	28514442
CHRC1_HUMAN	CHRAC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.