| UniProt ID | MES4_CAEEL | |
|---|---|---|
| UniProt AC | Q9NH52 | |
| Protein Name | Histone-lysine N-methyltransferase mes-4 | |
| Gene Name | mes-4 | |
| Organism | Caenorhabditis elegans. | |
| Sequence Length | 898 | |
| Subcellular Localization | Nucleus . Chromosome . Specifically associated with the autosomes and with the distal tip of chromosome X. Colocalizes with methylated 'Lys-4' of histone H3. | |
| Protein Description | Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. [PubMed: 12077420] | |
| Protein Sequence | MLPSSGDSSKENCAPQDGIVEKEGPNKPFKKKNVKQRNATPQGAGSETSSNAEDKQEEAPILTNAPKDIISMQIQETKAFLSEYEEFVDTDYPKTTFTHVPRKFLSVSPFTPIEADAEGEFLPDADSKCVICHEEKDKTGKSDLITCHGYINGEMDDGKRLLGNIPMFPCRSKFHASCMINYNSGGFHFQYAARLECQARLLCPLHCCNSCNLDHHKQSAYVGDIAECALCLRAFHLTSCYPSGGRDLNVSITIGGKVEKFEMIICPAHYLPGADVQFYNKHKKRKNAVTVVPKADVTMKSHIKACCVIGCEKSSNSKTIMCKTCCRSFHSGCREVETLNGKPIPDDQCESCVCGDPIPQNTLILAKWTDNSFWLALTLDWYKYPTGNRGNINFERLGYTVVQWLIPQENDKEKQPLMSIVPVSDIARLTKNYFSLAKNSTLRNLWEEKYEEQADTALKRCPYVCKTVFGRLRTSVYYKCEPKLEEYHNNEVCNCEGADRCTKLSCQYLADDYECPPSCSKKGVCHNRQVSMGIVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRRLDSVSISRDFQANHYMMELHKGLTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNNEENLPDCECGAENCMGTMGKAKREKPEVADSSEKAAKKNKSSKKKSVKNQNRKSQEAGKNGTASKKSEISPSKPSTSSASSTSFVQQASWPISQNKKNLKKNSNQPVADTGSTLSTSTELNFHEKPQELLSPVSSRSRAASSSTPRAQKSKSRRDDVESEAPPVKRATPSLQTIQETGKAIEFPATKSAITKARALSTQSVPSPHTVEVKVRAISTRGRVQKETKRFEPI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Phosphorylation | NVKQRNATPQGAGSE CCCCCCCCCCCCCCC | 21.50 | 30078680 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MES4_CAEEL !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MES4_CAEEL !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MES4_CAEEL !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CYC21_CAEEL | cyc-2.1 | physical | 14704431 | |
| LON1_CAEEL | lon-1 | physical | 14704431 | |
| CALX_CAEEL | cnx-1 | physical | 14704431 | |
| MOM2_CAEEL | mom-2 | genetic | 11904378 | |
| HMP2_CAEEL | hmp-2 | genetic | 11904378 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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