CYC21_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYC21_CAEEL
• UniProt AC: P19974
• Protein Name: Cytochrome c 2.1
• Gene Name: cyc-2.1
• Organism: Caenorhabditis elegans.
• Sequence Length: 111
• Subcellular Localization: Mitochondrion intermembrane space. Loosely associated with the inner membrane.
• Protein Description: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain..
• Protein Sequence: MSDIPAGDYEKGKKVYKQRCLQCHVVDSTATKTGPTLHGVIGRTSGTVSGFDYSAANKNKGVVWTKETLFEYLLNPKKYIPGTKMVFAGLKKADERADLIKYIEVESAKSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDIPAGDY ------CCCCCCCCH	44.22	2173902
9	Phosphorylation	SDIPAGDYEKGKKVY CCCCCCCHHHCCEEE	20.72	27067626
102	Phosphorylation	ERADLIKYIEVESAK HHHHHHHEEEHHHHC	8.70	27067626
110	Phosphorylation	IEVESAKSL------ EEHHHHCCC------	38.74	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYC21_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYC21_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYC21_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of CYC21_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"The primary structure of cytochrome c from the nematodeCaenorhabditis elegans.";
Vanfleteren J.R., Evers E.A.I.M., van de Werken G., van Beeumen J.J.;
Biochem. J. 271:613-620(1990).
Cited for: PROTEIN SEQUENCE OF 2-111, AND ACETYLATION AT SER-2.
PubMed: 2173902