MES3_CAEEL - dbPTM
MES3_CAEEL - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MES3_CAEEL
UniProt AC Q10665
Protein Name Polycomb protein mes-3
Gene Name mes-3
Organism Caenorhabditis elegans.
Sequence Length 754
Subcellular Localization Nucleus.
Protein Description Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to exclude mes-4 from the inactivated X-chromosomes in germline cells..
Protein Sequence MTPATAEVKVGGRKRKNDEPVFIKTKQSRSARREEEKENLLNKSLPSTPTSSEAGSSRESSNPVTSSSRRKNPPTKLENIQKTLPTCSDGLEIRNYVKKYGLPEDNKFLVRNVFDKQLLFGKKYVCRRRVIKSIDEFFPRLKTDAHRENGLYNFCTLQFMKISSWGSSMDEKIYVTSAAIVQSYVIIVDDNDSVTCIENGISVIPMANRTLPSISYNSSNVKNITLTGPELKKAKNVYLAVIVKRKTPKLGENRVGTRGKSTRASFETAASSENFQQLVRFGCTLMYDKDAEINCLNDGVQRIILLDREEKPAYLKIFGKADEPELENAWMNNVKHLEFISDTNYNKEDSHLARLIFSSNTHNYFDRPDISKFSPWQPRSRRTTLKSGISVEPGTSCDEDCGSQYEDTITLKQLLLGTKKLCGRRKRHLTRLTSRWPCFSVDPTKINSYFNETGVTLLENSCSYRPGTQRSIPIKPTRVIRVREETPVSVPIEVITIEDDSDDSPCFSARNRAPGGTRKYGLDFIQSSGHMPYIRYVYMNRANDLVPQLNGEENGKIEGLMEAYPMNNAHMYSDIEFLRKEKLNLPKNAQKYGEMTILDYPLTKTETDEYNKKMSVMNVKDFAVKPRKPIPTVGNTTLSLDLEGCPISTFSEIFFPSGKTELFNILCRHFYSEAGQRPGCFSAQWKSRVLTGFINKYHQYIFDMKLNSLFEKQINLIAMVSPDWKLEDFELPMVRYKQLKKEWKNRQRDIPSSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
486PhosphorylationVIRVREETPVSVPIE
EEEEEECCCCCCEEE
25.0019530675
489PhosphorylationVREETPVSVPIEVIT
EEECCCCCCEEEEEE
24.3119530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MES3_CAEEL !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MES3_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MES3_CAEEL !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DYL2_CAEELdlc-2physical
14704431
MOM2_CAEELmom-2genetic
11904378
HMP2_CAEELhmp-2genetic
11904378

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MES3_CAEEL

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Related Literatures of Post-Translational Modification

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