MEF2B_HUMAN - dbPTM
MEF2B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MEF2B_HUMAN
UniProt AC Q02080
Protein Name Myocyte-specific enhancer factor 2B
Gene Name MEF2B
Organism Homo sapiens (Human).
Sequence Length 365
Subcellular Localization Nucleus.
Protein Description Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription..
Protein Sequence MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYASTDMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEGGDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPPGLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTATPGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPSPIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASSEKTQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23UbiquitinationNRQVTFTKRKFGLMK
CCCCHHHHHHHCCCH		49.7732015554
57PhosphorylationSANRLFQYASTDMDR
CCCHHHHHCCCCHHH		8.6624043423
70PhosphorylationDRVLLKYTEYSEPHE
HHHHHHHHCCCCCCC		27.1930108239
72PhosphorylationVLLKYTEYSEPHESR
HHHHHHCCCCCCCCC		15.5530108239
73PhosphorylationLLKYTEYSEPHESRT
HHHHHCCCCCCCCCC		38.1230108239
78PhosphorylationEYSEPHESRTNTDIL
CCCCCCCCCCCHHHH		41.1730108239
89UbiquitinationTDILETLKRRGIGLD
HHHHHHHHHCCCCCC		47.6821906983
112UbiquitinationGPEEPGEKFRRLAGE
CCCCCCHHHHHHHCC		50.5121906983
139PhosphorylationPAAPAMPSPDVVYGA
CCCCCCCCCCCEEEC		22.2026714015
188PhosphorylationGLVHPLFSPSHLTSK
CCCCCCCCHHHHCCC		32.9330108239
190PhosphorylationVHPLFSPSHLTSKTP
CCCCCCHHHHCCCCC		29.9030108239
193PhosphorylationLFSPSHLTSKTPPPL
CCCHHHHCCCCCCCE		23.8230108239
194PhosphorylationFSPSHLTSKTPPPLY
CCHHHHCCCCCCCEE		40.6730108239
196PhosphorylationPSHLTSKTPPPLYLP
HHHHCCCCCCCEECC		40.5730108239
201PhosphorylationSKTPPPLYLPTEGRR
CCCCCCEECCCCCCC		19.1930108239
204PhosphorylationPPPLYLPTEGRRSDL
CCCEECCCCCCCCCC		48.7725332170
284PhosphorylationPQSASSLSASLRPPG
CCCHHHHCHHCCCCC		20.1224905233
286PhosphorylationSASSLSASLRPPGAP
CHHHHCHHCCCCCCC		22.8724905233
291 (in isoform 2)Phosphorylation-47.0426714015
294PhosphorylationLRPPGAPATFLRPSP
CCCCCCCCCEECCCC		15.51-
294 (in isoform 2)Phosphorylation-15.5126714015
298 (in isoform 2)Phosphorylation-26.0130108239
306 (in isoform 2)Phosphorylation-40.3625954137
310PhosphorylationPCSSPGPWQSLCGLG
CCCCCCCHHHHCCCC		13.3027251275
310 (in isoform 2)Phosphorylation-13.3030108239
313PhosphorylationSPGPWQSLCGLGPPC
CCCCHHHHCCCCCCC		1.2827251275
313 (in isoform 2)Phosphorylation-1.2830108239
317PhosphorylationWQSLCGLGPPCAGCP
HHHHCCCCCCCCCCC		14.91-
317 (in isoform 2)Phosphorylation-14.9124667141
319SumoylationSLCGLGPPCAGCPWP
HHCCCCCCCCCCCCC		20.84-
320 (in isoform 2)Phosphorylation-5.9826657352
324PhosphorylationGPPCAGCPWPTAGPG
CCCCCCCCCCCCCCC		38.8824719451
324 (in isoform 2)Phosphorylation-38.8826657352
334PhosphorylationTAGPGRRSPGGTSPE
CCCCCCCCCCCCCCC		26.9125954137
339PhosphorylationRRSPGGTSPERSPGT
CCCCCCCCCCCCCCC		28.2125954137
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MEF2B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MEF2B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MEF2B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TEX11_HUMANTEX11physical
16189514
CABIN_HUMANCABIN1physical
12700764
CABIN_HUMANCABIN1physical
10531067
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MEF2B_HUMAN

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Related Literatures of Post-Translational Modification

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