MAGI2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGI2_RAT
• UniProt AC: O88382
• Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
• Gene Name: Magi2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1277
• Subcellular Localization: Cytoplasm. Late endosome. Cell junction, synapse, synaptosome. Cell membrane; Peripheral membrane protein. Membrane-associated in synaptosomes. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endoso
• Protein Description: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth..
• Protein Sequence: MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAKGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSNNASPPEGFASHSLQTSDVIIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNNPTSAPSSEKQSPMAQQHSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTPGALPLPPPQACRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
250	Phosphorylation	NGNGVVITPESSEHE CCCCEEECCCCCCCC	14.92	30240740
362	Phosphorylation	EKIDDPIYGTYYVDH EECCCCCCCEEECCC	14.59	140321
366	Phosphorylation	DPIYGTYYVDHINRR CCCCCEEECCCCCCC	10.15	2001023
421	Ubiquitination	TRDASQLKGTFLSTT CCCHHHCCCEEEECE	48.55	-
547	Phosphorylation	GRHNYETYLEYISRT CCCCHHHHHHHHHHC	5.89	8312499
686	Phosphorylation	IHRGGFFSPWKTPKP EECCCCCCCCCCCCC	27.82	30411139
690	Phosphorylation	GFFSPWKTPKPMVDR CCCCCCCCCCCCCCC	32.45	19054758
703	Phosphorylation	DRWENQGSPQTSLSA CCCCCCCCCCCCCCC	12.22	27097102
706	Phosphorylation	ENQGSPQTSLSAPAV CCCCCCCCCCCCCCC	34.71	27097102
726	Phosphorylation	FPPALHRSSFPDSTE CCCHHCCCCCCCCCC	26.11	25403869
727	Phosphorylation	PPALHRSSFPDSTEA CCHHCCCCCCCCCCC	40.53	25403869
743	Phosphorylation	DPRKPDPYELYEKSR CCCCCCHHHHHHHHH	26.41	8086955
746	Phosphorylation	KPDPYELYEKSRAIY CCCHHHHHHHHHHHH	14.90	8309857
827	Phosphorylation	HPGDELVYVDGIPVA CCCCEEEEECCEECC	12.87	143711
875	Phosphorylation	PCPENGRSPGSVSTH CCCCCCCCCCCCCCC	34.70	27097102
878	Phosphorylation	ENGRSPGSVSTHHSS CCCCCCCCCCCCCCC	19.11	27097102
880	Phosphorylation	GRSPGSVSTHHSSPR CCCCCCCCCCCCCCC	24.58	27097102
881	Phosphorylation	RSPGSVSTHHSSPRS CCCCCCCCCCCCCCH	22.81	27097102
884	Phosphorylation	GSVSTHHSSPRSDYA CCCCCCCCCCCHHCC	34.14	27097102
885	Phosphorylation	SVSTHHSSPRSDYAT CCCCCCCCCCHHCCC	21.70	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGI2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGI2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGI2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DEND_RAT	Ddn	physical	16751601
GRASP_RAT	Grasp	physical	12586822

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.