DEND_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEND_RAT
• UniProt AC: P50617
• Protein Name: Dendrin
• Gene Name: Ddn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 707
• Subcellular Localization: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus. Enriched at the cytoplasmic insertion of the slit diaphragm into th
• Protein Description: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein..
• Protein Sequence: MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAASRQSMDIQASYWARGPQNRTCRLRPGSPEPPPRRPWASRVLQEATNWRAGPPAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPLGQPRPELRNALRAAQPTGFPVFSRPERFGQVGRAPRPSALPQGDPGVAWAGPWGGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPELSRAPTSSAPVPATTRTEGGRTKKRLDPRIYRDVLGAWGLRQGRGLLGGAPGCAAARARPESCKGAVEKSSGLAAAGLNSGGDGHSQAKTTGPVTEVALSGSTISSPPRPVPRSRQHLRGSRKGKEGSEEMWLPTCWLSSPKKPPVRHSQTLPRPWAPGGTGWKESLGQREGTEHETLEVWKVTRRAHTLPRSSRGPAGREGIFVIDATCVVIKSQYVPTPRTQQRQLAPSGESCIVSDSLRQPKPCLEEEGKGAAANPSVCQKRLLSSRVLNPPSEGREFEAEGRQQGDSSLEERSSSGLGFPVGEVNPRDAPTHPGSPEHSTLGPAAPGCAGSVKGPEAAGVPRRAGGGWARTPGPYAGALREAVSRIRRHTAPDSDSDEAEDLSAHSGSSDGSDTDAPGASWRNERTLPAVGNTRPREGGKTAELGDSIGEILDVISQTEEGLVREDTRKTPQGKRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	TCRLRPGSPEPPPRR CCCCCCCCCCCCCCC	28.86	25403869
138	Phosphorylation	KAGGARRSPLGQPRP HHCCCCCCCCCCCCH	20.94	30240740
349	Phosphorylation	TEVALSGSTISSPPR EEEEECCCCCCCCCC	21.13	25403869
350	Phosphorylation	EVALSGSTISSPPRP EEEECCCCCCCCCCC	28.53	25403869
352	Phosphorylation	ALSGSTISSPPRPVP EECCCCCCCCCCCCC	36.56	25403869
353	Phosphorylation	LSGSTISSPPRPVPR ECCCCCCCCCCCCCC	34.76	30240740
387	Phosphorylation	LPTCWLSSPKKPPVR CCCCHHCCCCCCCCC	38.27	-
396	Phosphorylation	KKPPVRHSQTLPRPW CCCCCCCCCCCCCCC	17.81	21630457
398	Phosphorylation	PPVRHSQTLPRPWAP CCCCCCCCCCCCCCC	41.57	21630457
436	Phosphorylation	KVTRRAHTLPRSSRG HHHCCCCCCCCCCCC	37.16	25403869
441	Phosphorylation	AHTLPRSSRGPAGRE CCCCCCCCCCCCCCC	42.40	26022182
515	Phosphorylation	VCQKRLLSSRVLNPP HHHHHHHHCCCCCCC	22.23	26022182
516	Phosphorylation	CQKRLLSSRVLNPPS HHHHHHHCCCCCCCC	26.78	26022182
538	Phosphorylation	EGRQQGDSSLEERSS CCCCCCCCCHHHHHC	43.58	25403869
539	Phosphorylation	GRQQGDSSLEERSSS CCCCCCCCHHHHHCC	44.53	25403869
566	Phosphorylation	DAPTHPGSPEHSTLG CCCCCCCCCCCCCCC	31.40	30240740
602	Phosphorylation	AGGGWARTPGPYAGA CCCCCCCCCCHHHHH	25.50	22673903
606	Phosphorylation	WARTPGPYAGALREA CCCCCCHHHHHHHHH	24.47	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEND_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEND_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEND_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAGI2_RAT	Magi2	physical	16751601

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.