MAGI1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGI1_MOUSE
• UniProt AC: Q6RHR9
• Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
• Gene Name: Magi1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1471
• Subcellular Localization: Isoform 2: Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell junction, tight junction. Localizes to epithelial cells tight junctions..; Isoform 3: Cytoplasm . Cell membrane ; Peripheral membrane protein .; Isoform 1: Nucleus .
• Protein Description: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface..
• Protein Sequence: MSKVIQKKNHWTGRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAAEAAGLPGGGEGPKLAEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYSFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHPENEEEEDVPEMNSSFTADSGDQDEHTLQEATLPPVNSSILAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQPQPPQPEEWTEDHASVVPPVAPSHPPSNPEPARETPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSSMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHGIQVLPEYLPADAPAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSAVLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHAPSQQGTQETRTTTKPKQDSQFEFKGPQAAQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEVRPGPPDHRPHPALESSYPPELHKSSQHAEKRAHAKDPKGNREHSKQPNEHHTWNGTSRKQDSGACRPKDRPPDAWREAQPERTATNGSKRRSPEKRREGTRSADNTLERREKHEKRREISPERKRERSPTRRKDSSPSRRRRSLERLLDQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNRDDKVGHREREEAGLKLEAGRSPRNPPEQRRRPYKECSTDLSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MSKVIQKKNH -----CCCCCCCCCC	56.04	55169475
145	Phosphorylation	YRHAVPCTTRSPREG HHHCCCCCCCCCCCC	21.12	26643407
146	Phosphorylation	RHAVPCTTRSPREGE HHCCCCCCCCCCCCC	35.55	26643407
148	Phosphorylation	AVPCTTRSPREGEVP CCCCCCCCCCCCCCC	26.64	26824392
209	Phosphorylation	ITTDALHSLQSGSKQ EEHHHHHHHHCCCCC	29.02	26824392
212	Phosphorylation	DALHSLQSGSKQSTP HHHHHHHCCCCCCCC	50.78	25338131
214	Phosphorylation	LHSLQSGSKQSTPKR HHHHHCCCCCCCCCC	32.54	27841257
357	Phosphorylation	VHTEELDSELELPAG CCHHHCCCCEECCCC	57.62	23608596
373	Phosphorylation	EKIEDPVYGVYYVDH EECCCCCCEEEEEEC	13.28	21890632
377	Phosphorylation	DPVYGVYYVDHINRK CCCCEEEEEECCCCC	9.30	17242355
470	Phosphorylation	IHTKLRKSSRGFGFT EEHHCCCCCCCCCEE	20.87	26643407
471	Phosphorylation	HTKLRKSSRGFGFTV EHHCCCCCCCCCEEE	39.18	26643407
477	Phosphorylation	SSRGFGFTVVGGDEP CCCCCCEEEECCCCC	18.05	26643407
580	Phosphorylation	IIVNGQETYDSPASH EEECCEEECCCCCCC	25.41	29899451
581	Phosphorylation	IVNGQETYDSPASHS EECCEEECCCCCCCC	17.42	29899451
583	Phosphorylation	NGQETYDSPASHSSK CCEEECCCCCCCCCC	16.38	29899451
591	Phosphorylation	PASHSSKTGKVSSMK CCCCCCCCCCCCCCC	44.15	-
603	Phosphorylation	SMKDARPSSPADVAS CCCCCCCCCHHHHHC	43.32	26239621
604	Phosphorylation	MKDARPSSPADVASN CCCCCCCCHHHHHCC	27.13	26239621
610	Phosphorylation	SSPADVASNSSHGYP CCHHHHHCCCCCCCC	36.77	26160508
612	Phosphorylation	PADVASNSSHGYPND HHHHHCCCCCCCCCC	22.63	26160508
613	Phosphorylation	ADVASNSSHGYPNDT HHHHCCCCCCCCCCC	25.78	23984901
616	Phosphorylation	ASNSSHGYPNDTVSL HCCCCCCCCCCCCCH	8.08	26160508
620	Phosphorylation	SHGYPNDTVSLASSI CCCCCCCCCCHHHHH	20.73	23984901
622	Phosphorylation	GYPNDTVSLASSIAT CCCCCCCCHHHHHHC	21.95	23984901
625	Phosphorylation	NDTVSLASSIATQPE CCCCCHHHHHHCCCC	27.80	23984901
626	Phosphorylation	DTVSLASSIATQPEL CCCCHHHHHHCCCCE	15.61	23984901
666	Phosphorylation	RVKQIVDSPRCRGLK HHHHHCCCCCCCCCC	11.89	22817900
722	Phosphorylation	GLPVPKKSPKSQPLE CCCCCCCCCCCCCCC	43.62	26824392
725	Phosphorylation	VPKKSPKSQPLERKD CCCCCCCCCCCCCCC	40.18	29514104
733	Phosphorylation	QPLERKDSQNSSQHS CCCCCCCCCCCCCCC	34.01	27087446
736	Phosphorylation	ERKDSQNSSQHSVSS CCCCCCCCCCCCHHH	24.60	27087446
737	Phosphorylation	RKDSQNSSQHSVSSH CCCCCCCCCCCHHHC	39.19	27087446
740	Phosphorylation	SQNSSQHSVSSHRSL CCCCCCCCHHHCCCC	18.96	23684622
742	Phosphorylation	NSSQHSVSSHRSLHT CCCCCCHHHCCCCCC	24.36	29472430
743	Phosphorylation	SSQHSVSSHRSLHTA CCCCCHHHCCCCCCC	22.29	29472430
746	Phosphorylation	HSVSSHRSLHTASPS CCHHHCCCCCCCCCC	21.05	26643407
749	Phosphorylation	SSHRSLHTASPSHGI HHCCCCCCCCCCCCC	33.84	26643407
751	Phosphorylation	HRSLHTASPSHGIQV CCCCCCCCCCCCCEE	28.26	26643407
753	Phosphorylation	SLHTASPSHGIQVLP CCCCCCCCCCCEECC	31.67	26643407
762	Phosphorylation	GIQVLPEYLPADAPA CCEECCCCCCCCCCC	18.95	25293948
773	Phosphorylation	DAPAPDQTDSSGQKK CCCCCCCCCCCCCCC	45.27	25777480
775	Phosphorylation	PAPDQTDSSGQKKPD CCCCCCCCCCCCCCC	39.49	25777480
776	Phosphorylation	APDQTDSSGQKKPDP CCCCCCCCCCCCCCH	48.31	25777480
792	Phosphorylation	KIWAQSRSMYENRPM HHHHCCCCHHHCCCC	30.85	22817900
800	Phosphorylation	MYENRPMSPSPASGL HHHCCCCCCCCCCCC	25.55	26643407
802	Phosphorylation	ENRPMSPSPASGLSK HCCCCCCCCCCCCCC	26.28	26643407
805	Phosphorylation	PMSPSPASGLSKGER CCCCCCCCCCCCCCC	43.58	26643407
808	Phosphorylation	PSPASGLSKGERDRE CCCCCCCCCCCCCCC	41.98	26643407
829	Phosphorylation	GECQIPDYQEQDIFL CCCCCCCCCCCCEEE	14.48	-
858	Phosphorylation	NEPGEPIYIGHIVPL CCCCCCEEEEEEEEC	16.15	21890632
930	Phosphorylation	KAENEVPSPASSHHS CCCCCCCCCCCCCCC	37.97	26643407
933	Phosphorylation	NEVPSPASSHHSSNQ CCCCCCCCCCCCCCC	33.32	26643407
934	Phosphorylation	EVPSPASSHHSSNQP CCCCCCCCCCCCCCC	27.59	26643407
937	Phosphorylation	SPASSHHSSNQPASL CCCCCCCCCCCCCCC	26.09	26643407
938	Phosphorylation	PASSHHSSNQPASLT CCCCCCCCCCCCCCC	34.82	26643407
943	Phosphorylation	HSSNQPASLTEEKRT CCCCCCCCCCCCCCC	42.37	26643407
945	Phosphorylation	SNQPASLTEEKRTPQ CCCCCCCCCCCCCCC	39.33	26643407
1051	Phosphorylation	GCSITNKSHSDIVNL CEECCCCCHHHHHHH	30.23	25521595
1053	Phosphorylation	SITNKSHSDIVNLIK ECCCCCHHHHHHHHH	35.80	25521595
1093	O-linked_Glycosylation	EKIATITTTHAPSQQ HHEEEEEECCCCCCC	16.85	22517741
1094	O-linked_Glycosylation	KIATITTTHAPSQQG HEEEEEECCCCCCCC	13.85	22517741
1120 (in isoform 2)	Phosphorylation	-	63.58	23140645
1145	Phosphorylation	GAKGFGFSLRGGREY CCCCCCEEECCCCEE	19.96	29472430
1200	Acetylation	SRAIELIKNGGRRVR HHHHHHHHCCCEEEE	63.26	8277257
1235 (in isoform 3)	Phosphorylation	-	36.09	29899451
1328	Acetylation	RTATNGSKRRSPEKR CCCCCCCCCCCHHHH	53.91	22902405
1339	Phosphorylation	PEKRREGTRSADNTL HHHHHHCCCCCHHHH	19.39	29550500
1341	Phosphorylation	KRREGTRSADNTLER HHHHCCCCCHHHHHH	39.55	25521595
1345	Phosphorylation	GTRSADNTLERREKH CCCCCHHHHHHHHHH	30.46	26824392
1359	Phosphorylation	HEKRREISPERKRER HHHHHCCCHHHHHHC	18.89	26824392
1374	Phosphorylation	SPTRRKDSSPSRRRR CCCCCCCCCHHHHHH	47.38	23737553
1375	Phosphorylation	PTRRKDSSPSRRRRS CCCCCCCCHHHHHHH	36.71	23737553
1377	Phosphorylation	RRKDSSPSRRRRSLE CCCCCCHHHHHHHHH	40.13	23737553
1392	Phosphorylation	RLLDQRRSPERRRGG HHHHHCCCHHHHCCC	33.05	30352176
1400	Phosphorylation	PERRRGGSPERRAKS HHHHCCCCHHHHHHH	26.81	21454597
1415	Phosphorylation	TDRRRARSPERRRER HHHHHHHCHHHHHHH	30.08	-
1423	Phosphorylation	PERRRERSLDKRNRD HHHHHHHHHHHCCCC	35.85	26824392
1450	Phosphorylation	LKLEAGRSPRNPPEQ CCCCCCCCCCCCHHH	27.56	24899341
1466	Phosphorylation	RRPYKECSTDLSI-- CCCCCCCCCCCCC--	26.50	21659604
1467	Phosphorylation	RPYKECSTDLSI--- CCCCCCCCCCCC---	53.25	21743459
1470	Phosphorylation	KECSTDLSI------ CCCCCCCCC------	29.12	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGI1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGI1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGI1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMOL1_HUMAN	AMOTL1	physical	16019084
IGSF5_MOUSE	Igsf5	physical	12773569

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain.";
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
J. Proteome Res. 7:311-318(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-858, AND MASSSPECTROMETRY.
PubMed: 18034455