IGSF5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IGSF5_MOUSE
• UniProt AC: Q7TSN7
• Protein Name: Immunoglobulin superfamily member 5
• Gene Name: Igsf5
• Organism: Mus musculus (Mouse).
• Sequence Length: 370
• Subcellular Localization: Apical cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction .
• Protein Description: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells..
• Protein Sequence: MEGSWRDVLAVLVILAQLTASGSSYQIIEGPQNVTVLKDSEAHFNCTVTHGWKLLMWTLNQMVVLSLTTQGPIITNNRFTYASYNSTDSFISELIIHDVQPSDSGSVQCSLQNSHGFGSAFLSVQVMGTLNIPSNNLIVTEGEPCNVTCYAVGWTSLPDISWELEVPVSHSSYNSFLESGNFMRVLSVLDLTPLGNGTLTCVAELKDLQASKSLTVNLTVVQPPPDSIGEEGPALPTWAIILLAVAFSLLLILIIVLIIIFCCCCASRREKEESTYQNEIRKSANMRTNKADPETKLKGGKENYGYSSDEAKAAQTASLPPKSAEVSLPEKRSSSLPYQELNKHQPGPATHPRVSFDIASPQKVRNVTLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	QIIEGPQNVTVLKDS EEEECCCEEEEECCC	34.26	-
45	N-linked_Glycosylation	KDSEAHFNCTVTHGW CCCCCCCCCEEECHH	15.64	-
146	N-linked_Glycosylation	VTEGEPCNVTCYAVG EECCCCCEEEEEEEE	42.73	-
196	N-linked_Glycosylation	LDLTPLGNGTLTCVA EEEECCCCCEEEEEE	48.21	-
217	N-linked_Glycosylation	ASKSLTVNLTVVQPP CCCCEEEEEEEEECC	25.43	-
333	Phosphorylation	VSLPEKRSSSLPYQE CCCCCCCCCCCCHHH	35.03	29472430
334	Phosphorylation	SLPEKRSSSLPYQEL CCCCCCCCCCCHHHH	39.67	29472430
335	Phosphorylation	LPEKRSSSLPYQELN CCCCCCCCCCHHHHH	34.31	29472430
355	Phosphorylation	PATHPRVSFDIASPQ CCCCCCEEEEECCCC	20.62	26239621
360	Phosphorylation	RVSFDIASPQKVRNV CEEEEECCCCCEECE	28.35	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IGSF5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IGSF5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IGSF5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_MOUSE	Lnx1	physical	16832352
NUMB_MOUSE	Numb	physical	16832352

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.