M3K13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K13_HUMAN
• UniProt AC: O43283
• Protein Name: Mitogen-activated protein kinase kinase kinase 13
• Gene Name: MAP3K13 {ECO:0000312|HGNC:HGNC:6852}
• Organism: Homo sapiens (Human).
• Sequence Length: 966
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein .
• Protein Description: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B..
• Protein Sequence: MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKHYSSATW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	QEKGMVRTELIESVH HHHCCHHHHHHHHCC	24.59	24719451
57	Ubiquitination	GMVRTELIESVHSPV CCHHHHHHHHCCCCC	2.78	22505724
59	Phosphorylation	VRTELIESVHSPVTT HHHHHHHHCCCCCCE	20.38	24719451
121 (in isoform 6)	Phosphorylation	-	14.79	26270265
123 (in isoform 6)	Phosphorylation	-	35.79	26270265
126 (in isoform 6)	Phosphorylation	-	33.56	26270265
206	Ubiquitination	EQNETDIKHLRKLKH HCCCCCHHHHHHCCC	39.12	22505724
282	Phosphorylation	IIHRDLKSPNVLVTH HHCCCCCCCCEEEEE	29.07	-
288	Phosphorylation	KSPNVLVTHTDAVKI CCCCEEEEECCEEEH	18.20	-
296	Phosphorylation	HTDAVKISDFGTSKE ECCEEEHHHCCCCHH	22.59	24905233
300	Phosphorylation	VKISDFGTSKELSDK EEHHHCCCCHHHCCC	36.30	24905233
301	Phosphorylation	KISDFGTSKELSDKS EHHHCCCCHHHCCCC	25.22	24905233
305	Phosphorylation	FGTSKELSDKSTKMS CCCCHHHCCCCCCCC	44.05	24905233
308	Phosphorylation	SKELSDKSTKMSFAG CHHHCCCCCCCCHHH	37.95	24905233
309	Phosphorylation	KELSDKSTKMSFAGT HHHCCCCCCCCHHHH	36.18	24905233
312	Phosphorylation	SDKSTKMSFAGTVAW CCCCCCCCHHHHHHH	17.32	28348404
365	Phosphorylation	SSAIIWGVGSNSLHL CCCEEEEECCCCEEC	4.58	32142685
399	Phosphorylation	SKPRNRPSFRQTLMH CCCCCCHHHHHHHHH	29.80	23607784
403	Phosphorylation	NRPSFRQTLMHLDIA CCHHHHHHHHHHHHH	23.07	23607784
411	Phosphorylation	LMHLDIASADVLATP HHHHHHHCCCCCCCC	25.90	23607784
417	Phosphorylation	ASADVLATPQETYFK HCCCCCCCCHHHHCH	22.73	23607784
421	Phosphorylation	VLATPQETYFKSQAE CCCCCHHHHCHHHHH	29.07	23607784
422	Phosphorylation	LATPQETYFKSQAEW CCCCHHHHCHHHHHH	14.30	23607784
474	Phosphorylation	DIREHYERKLERANN HHHHHHHHHHHHHHH	41.51	32142685
483	Phosphorylation	LERANNLYMELSAIM HHHHHHHHHHHHHHH	7.23	-
502	Acetylation	MREKELIKREQAVEK HHHHHHHHHHHHHHH	63.61	20167786
511	Phosphorylation	EQAVEKKYPGTYKRH HHHHHHHCCCCCCCC	20.26	-
541	"N6,N6-dimethyllysine"	KRKGVPHKSGMQTKR HHHCCCCCCCCCCCC	42.51	-
541	Methylation	KRKGVPHKSGMQTKR HHHCCCCCCCCCCCC	42.51	-
565	Phosphorylation	PTTEVAPTASPLSGS CCCCCCCCCCCCCCC	29.99	27732954
567	Phosphorylation	TEVAPTASPLSGSPK CCCCCCCCCCCCCCC	28.93	27732954
570	Phosphorylation	APTASPLSGSPKMST CCCCCCCCCCCCCCC	40.38	26657352
572	Phosphorylation	TASPLSGSPKMSTSS CCCCCCCCCCCCCCC	20.26	26657352
578	Phosphorylation	GSPKMSTSSSKSRYR CCCCCCCCCCCHHCC	25.88	-
579	Phosphorylation	SPKMSTSSSKSRYRS CCCCCCCCCCHHCCC	41.70	-
672	Phosphorylation	TCANNLRYFGPAAAL HHHHHCHHCCCHHHH	18.96	23312004
681	Phosphorylation	GPAAALRSPLSNHAQ CCHHHHHCCCCHHHH	30.92	32142685
684	Phosphorylation	AALRSPLSNHAQRQL HHHHCCCCHHHHHHC	29.92	23312004
694	Phosphorylation	AQRQLPGSSPDLIST HHHHCCCCCHHHHHH	36.44	28348404
695	Phosphorylation	QRQLPGSSPDLISTA HHHCCCCCHHHHHHH	28.48	28348404
789	Phosphorylation	SGCRSESSLGTSHLG CCCCCCCCCCCCCCC	27.11	-
797	Phosphorylation	LGTSHLGTPPALPRK CCCCCCCCCCCCCCC	32.24	28348404
811	Phosphorylation	KTRPLQKSGDDSSEE CCCCCCCCCCCCCCC	34.20	-
892	Phosphorylation	LDDLLSQTPEIPIDI HHHHHHCCCCCCCCC	21.36	28348404
900	Phosphorylation	PEIPIDISSHSDGLS CCCCCCCCCCCCCCC	20.46	28348404
901	Phosphorylation	EIPIDISSHSDGLSD CCCCCCCCCCCCCCC	27.61	28348404
903	Phosphorylation	PIDISSHSDGLSDKE CCCCCCCCCCCCCHH	35.01	28348404
907	Phosphorylation	SSHSDGLSDKECAVR CCCCCCCCCHHHHHH	52.76	28348404
921	Phosphorylation	RRVKTQMSLGKLCVE HHHHHHHHHCCHHHH	24.93	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M3K13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDX3_HUMAN	PRDX3	physical	12492477
M3K13_HUMAN	MAP3K13	physical	11163770
MP2K7_HUMAN	MAP2K7	physical	11726277
STAT3_HUMAN	STAT3	physical	21988832
H2A2C_HUMAN	HIST2H2AC	physical	28514442
SHIP2_HUMAN	INPPL1	physical	28514442
KLH20_HUMAN	KLHL20	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.