LRRN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRN3_HUMAN
• UniProt AC: Q9H3W5
• Protein Name: Leucine-rich repeat neuronal protein 3
• Gene Name: LRRN3
• Organism: Homo sapiens (Human).
• Sequence Length: 708
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MKDMPLRIHVLLGLAITTLVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVGADLKSVMIKVDGSFPQDNNGSLNIKIRDIQANSVLVSWKASSKILKSSVKWTAFVKTENSHAAQSARIPSDVKVYNLTHLNPSTEYKICIDIPTIYQKNRKKCVNVTTKGLHPDQKEYEKNNTTTLMACLGGLLGIIGVICLISCLSPEMNCDGGHSYVRNYLQKPTFALGELYPPLINLWEAGKEKSTSLKVKATVIGLPTNMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	N-linked_Glycosylation	YSTDFPVNLTGLDLS EECCCCCCCCCCCCC	31.93	UniProtKB CARBOHYD
103	N-linked_Glycosylation	GLDLSQNNLSSVTNI CCCCCCCCCCCCCCC	33.39	UniProtKB CARBOHYD
120	Phosphorylation	KKMPQLLSVYLEENK HCCHHHHHHHHHCCC	19.80	29396449
122	Phosphorylation	MPQLLSVYLEENKLT CHHHHHHHHHCCCCC	12.67	29396449
223	N-linked_Glycosylation	SLVIAGINLTEIPDN HEEEECCCCCCCCCC	39.74	UniProtKB CARBOHYD
338	Phosphorylation	FRLPKLESLMLNSNA CCCCCHHHHHCCCHH	29.52	29759185
350	Phosphorylation	SNALSALYHGTIESL CHHHHHHHHCCHHHC	9.64	29759185
382	N-linked_Glycosylation	VIRWMNMNKTNIRFM EEEEECCCCCCEEEE	42.89	UniProtKB CARBOHYD
522	N-linked_Glycosylation	GSFPQDNNGSLNIKI CCCCCCCCCCEEEEE	50.12	UniProtKB CARBOHYD
579	N-linked_Glycosylation	PSDVKVYNLTHLNPS CCCCEEEECCCCCCC	41.26	UniProtKB CARBOHYD
608	N-linked_Glycosylation	KNRKKCVNVTTKGLH HCCHHCCCCCCCCCC	34.58	UniProtKB CARBOHYD
624	N-linked_Glycosylation	DQKEYEKNNTTTLMA CHHHHHHCCHHHHHH	38.86	UniProtKB CARBOHYD
625	N-linked_Glycosylation	QKEYEKNNTTTLMAC HHHHHHCCHHHHHHH	50.28	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CALL5_HUMAN	CALML5	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.