LRRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRRN1_HUMAN
• UniProt AC: Q6UXK5
• Protein Name: Leucine-rich repeat neuronal protein 1
• Gene Name: LRRN1
• Organism: Homo sapiens (Human).
• Sequence Length: 716
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLRSLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGADTRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNPHITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFAVDISDQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQKTSSIPLNELYPPLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	TQVLLLQSNNIAKTV CEEEEEECCCHHHHH	31.64	-
96	N-linked_Glycosylation	DELQQLFNLTELDFS HHHHHHHCCCCCCCC	55.43	UniProtKB CARBOHYD
117	N-linked_Glycosylation	IKEVGLANLTQLTTL HHHHCEECCCEEEEE	48.98	UniProtKB CARBOHYD
306	Phosphorylation	ELVSVDRYALDNLPE CEEEEEHHHHHCCCH	13.67	-
320	Phosphorylation	ELTKLEATNNPKLSY HHHHHCCCCCCCCHH	26.59	26270265
326	Phosphorylation	ATNNPKLSYIHRLAF CCCCCCCHHHHHHHH	28.32	30631047
327	Phosphorylation	TNNPKLSYIHRLAFR CCCCCCHHHHHHHHC	15.93	30631047
385	N-linked_Glycosylation	VIHWINSNKTNIRFM EEEEECCCCCEEEEE	51.16	UniProtKB CARBOHYD
468	Phosphorylation	TPIGNKITVETLSDK ECCCCEEEEEECCCC	17.56	21406692
471	Phosphorylation	GNKITVETLSDKYKL CCEEEEEECCCCEEE	27.50	21406692
473	Phosphorylation	KITVETLSDKYKLSS EEEEEECCCCEEECC	39.20	21406692
476	Phosphorylation	VETLSDKYKLSSEGT EEECCCCEEECCCCE	23.35	21406692
479	Phosphorylation	LSDKYKLSSEGTLEI CCCCEEECCCCEEEE	23.38	-
517	N-linked_Glycosylation	RVATIKVNGTLLDGT EEEEEEECCEEECCE	32.50	UniProtKB CARBOHYD
552	Phosphorylation	VNSNVMTSNLKWSSA ECCCCCCCCEEEEEE	23.28	30631047
557	Phosphorylation	MTSNLKWSSATMKID CCCCEEEEEEEEEEC	14.44	30631047
558	Phosphorylation	TSNLKWSSATMKIDN CCCEEEEEEEEEECC	27.00	30631047
571	O-linked_Glycosylation	DNPHITYTARVPVDV CCCCEEEEEEECCEE	10.19	55826169
664	Phosphorylation	KRKNYHHSLKKYMQK HHCCCHHHHHHHHHH	28.68	21406692
667	Ubiquitination	NYHHSLKKYMQKTSS CCHHHHHHHHHHHCC	51.77	-
672	Phosphorylation	LKKYMQKTSSIPLNE HHHHHHHHCCCCHHH	15.71	24173317
673	Phosphorylation	KKYMQKTSSIPLNEL HHHHHHHCCCCHHHH	33.05	24173317
674	Phosphorylation	KYMQKTSSIPLNELY HHHHHHCCCCHHHHC	33.19	28348404
709	Phosphorylation	TKPTQVDTSRSYYMW CCCCCCCCCCCCCCC	27.47	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRRN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRRN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTPRD_HUMAN	PTPRD	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
ST7_HUMAN	ST7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.