LRP2_MOUSE - dbPTM
LRP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRP2_MOUSE
UniProt AC A2ARV4
Protein Name Low-density lipoprotein receptor-related protein 2
Gene Name Lrp2
Organism Mus musculus (Mouse).
Sequence Length 4660
Subcellular Localization Apical cell membrane
Single-pass type I membrane protein . Endosome lumen . Membrane, coated pit . Cell projection, dendrite . Cell projection, axon . Localizes to brush border membranes in the kidney. In the endolymphatic sac of the inner ear, loc
Protein Description Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. [PubMed: 10766831 Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity In the kidney, mediates the tubular uptake and clearance of leptin]
Protein Sequence MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSFSAASIIFSNGRDLLVGDLHGRNFRILAESKNRGIVMGVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKANKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCEFGFELDADEHHCVAVKNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTIFYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQIISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTHPFGLTVFKDNVFLTDWRLGAIIRVRKSDGGDMTVVRRGISSIMHVKAYDADLQTGTNYCSQTTHPNGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGCVLNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQWQCPGYSICVNLSALCDGVFDCPNGTDESPLCNQDSCLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTCEDVNECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTASENLLLVVASRDKIIMDNITAHTHNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSAFQNGTDKRVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQANKWHGRNQSVVMYSVPQPLGIIAIHPSRQPSSPNPCASATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNCVRGDQPFLISVRENVIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTAFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILVHHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPNGSNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHIVVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASKQPGNTDPPTVIRDSINLLRDVTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPKCGCAFGTLEDDGKNCATSREDFLIYSLNNSLRSLHFDPQDHNLPFQAISVEGMAIALDYDRRNNRIFFTQKLNPIRGQISYVNLYSGASSPTILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERSTLTGSNREVVISTAFHSFGLTVYGQYIYWTDFYTKKIYRANKYDGSDLIAMTTRLPTQPSGISTVVKTQQQQCSNPCDQFNGGCSHICAPGPNGAECQCPHEGSWYLANDNKYCVVDTGARCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGCLFRSCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPITCQPDFAKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCVSPHRCIPSYWFCDGEADCVDSSDEPDTCGHSLNSCSANQFHCDNGRCISSSWVCDGDNDCGDMSDEDQRHHCELQNCSSTEFTCINSRPPNRRCIPQHWVCDGDADCADALDELQNCTMRACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGCSYPPCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINECQDSSISHCDHNCTDTITSFYCSCLPGYKLMSDKRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKSCRQNSNIEPYLVFSNRYYIRNLTIDGTSYSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTNQETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQRKMLAQHCVDANNTFCFENPRGIVLHPQRGYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGTLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVLHPYRQPIMSNPCATNNGGCSHLCLIKAGGRGFTCECPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDESDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIHECMTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESCVPRECTESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNVPCESPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGCNLGENRTCAEKICEQNCTQLSNGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNISSEKFSEYLEEEEHIQAIDYDWDPEGIGLSVVYYTVLSQGSQFGAIKRAYLPDFESGSNNPVREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDYLNGDRIYWSDSKEDVIESIKYDGTDRRLIINDAMKPFSLDIFEDQLYWVAKEKGEVWRQNKFGKGNKEKLLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVECDAASELPITMPSPCRCMHGGSCYFDENDLPKCKCSSGYSGEYCEIGLSRGIPPGTTMALLLTFAMVIIVGALVLVGFFHYRKTGSLLPSLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEQFVMEVGKQPVIFENPMYAAKDSTSKVGLAVQGPSVSSQVTVPENVENQNYGRSIDPSEIVPEPKPASPGADETQGTKWNIFKRKPKQTTNFENPIYAEMDTEQKEAVAVAPPPSPSLPAKASKRSSTPGYTATEDTFKDTANLVKEDSDV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
159N-linked_GlycosylationCANGACYNTSQKCDH
ECCCCEECCCCCCCC		32.89-
178N-linked_GlycosylationRDSSDEANCTTLCSQ
CCCCCCCCCCEEECC		22.94-
299N-linked_GlycosylationPEGEDENNATSGRYC
CCCCCCCCCCCCCCC		42.41-
340N-linked_GlycosylationPGHIINSNDSRTCID
CCCEECCCCCCEEEC		46.95-
387N-linked_GlycosylationRGQHCKSNDSFSAAS
CCCCCCCCCCCCCEE		34.1519349973
399N-linked_GlycosylationAASIIFSNGRDLLVG
CEEEEEECCCEEEEE		38.4819349973
462N-linked_GlycosylationLNTQEILNVSIDAPE
CCHHHEEEEECCCCC		31.02-
553PhosphorylationNRKDLVTTKLGWPAG
CCHHHEECCCCCCCC		19.4522871156
571PhosphorylationDLVSKRVYWVDSRYD
EHHHCEEEEECCCCC		12.0728576409
657N-linked_GlycosylationYHALRQPNATNPCGN
HHHHCCCCCCCCCCC		51.57-
804PhosphorylationLYWTDGGSKSVTVMK
EEECCCCCCEEEEEE		27.5624719451
865N-linked_GlycosylationSHLMPIVNTSLGWPN
CCCCCEECCCCCCCC		25.35-
1063N-linked_GlycosylationEHQCGALNNTCSSSA
HHCCCCCCCCCCCCC		41.03-
1187N-linked_GlycosylationDEAGCVLNCTSSQFK
CCCCEEEECCCCCEE		13.46-
1328N-linked_GlycosylationPGYSICVNLSALCDG
CCCEEEEEHHHHCCC		24.70-
1341N-linked_GlycosylationDGVFDCPNGTDESPL
CCEECCCCCCCCCCC		72.78-
1384N-linked_GlycosylationPIGYQLANDTKTCED
CCCEEECCCCCCCCC		67.10-
1451N-linked_GlycosylationRDKIIMDNITAHTHN
CCEEEEECCHHHCCC		19.01-
1497N-linked_GlycosylationKTWSAFQNGTDKRVV
CCCEECCCCCCCCEE		49.21-
1551N-linked_GlycosylationRTVLISKNVTKPRGL
CEEEEECCCCCCCCC		39.64-
1676N-linked_GlycosylationANKWHGRNQSVVMYS
CCCCCCCCCEEEEEE		42.97-
1696PhosphorylationGIIAIHPSRQPSSPN
EEEEECCCCCCCCCC		29.41-
1733N-linked_GlycosylationCACPSGWNLSDDSVN
CCCCCCCCCCCCCCC		32.94-
1811N-linked_GlycosylationRVKTDGSNRTAFAPL
EEECCCCCCEECCCH		51.34-
2131N-linked_GlycosylationGIRRIKPNGSNFTNI
CCEECCCCCCCCCCE		62.62-
2134N-linked_GlycosylationRIKPNGSNFTNIVTY
ECCCCCCCCCCEEEE		49.51-
2178N-linked_GlycosylationLIEVIRINTTYRRVL
HHHHHHCCCCCCEEE		19.27-
2201AcetylationRHIVVDPKHRYLFWA
CEEEECCCCCEEEEE		35.9330986553
2225N-linked_GlycosylationRSFLDCTNRTVLVSE
EEEECCCCCEEEEEC		43.91-
2396N-linked_GlycosylationDFLIYSLNNSLRSLH
HEEEEECCCCCHHCC		30.06-
2439UbiquitinationNRIFFTQKLNPIRGQ
CEEEEEEECCCCCCC		47.3722790023
2488N-linked_GlycosylationIYYSDFSNQTINSMA
EEEECCCCCCHHHHH		42.90-
2499PhosphorylationNSMAEDGSNRAVIAR
HHHHCCCCCCEEEEE		35.15-
2548N-linked_GlycosylationNFRVPIVNTSLVWPN
CEEEEEEECCEECCC		25.35-
2782N-linked_GlycosylationGCLFRSCNSTTEFTC
CEEEECCCCCCEEEE		43.57-
2810N-linked_GlycosylationGINNCHDNDTSDEKN
CCCCCCCCCCCCCCC		30.69-
2949N-linked_GlycosylationRHHCELQNCSSTEFT
HHCEEECCCCCCCEE		40.02-
2989N-linked_GlycosylationDALDELQNCTMRACS
HHHHHHHHCCCHHHC		35.53-
3127N-linked_GlycosylationSISHCDHNCTDTITS
CCCCCCCCCCHHHHH		19.68-
3213N-linked_GlycosylationSNRYYIRNLTIDGTS
CCCEEEEEEEECCCC		31.79-
3244PhosphorylationDRVEERLYWIDAEKQ
HHHHHHEEEEHHHHH		13.41-
3259N-linked_GlycosylationIIERMFLNKTNQETI
HHHHHHCCCCCHHHH		37.53-
3317N-linked_GlycosylationAQHCVDANNTFCFEN
HHHCCCCCCCEEEEC		43.54-
3357N-linked_GlycosylationRIGMDGTNKTVIIST
EEECCCCCCEEEEEC		43.46-
3448N-linked_GlycosylationSGRVVLVNTTHKPFD
CCCEEEEECCCCCEE		34.79-
3566N-linked_GlycosylationQFQCRDGNCTSPQAL
CEECCCCCCCCHHHH		30.13-
3682N-linked_GlycosylationTAAYNCDNHTEFSCK
HHHHCCCCCCCCCCC		46.29-
3840N-linked_GlycosylationACPTRFPNGTYCPAA
CCCCCCCCCCCCCHH		53.37-
3969N-linked_GlycosylationTGCNLGENRTCAEKI
CCCCCCCCCHHHHHH		42.64-
3980N-linked_GlycosylationAEKICEQNCTQLSNG
HHHHHHCCCCCCCCC		14.44-
4070N-linked_GlycosylationNVRIRKYNISSEKFS
CEEEEECCCCCHHHH		30.60-
4164UbiquitinationHIYWSDAKSQRIEVA
CEECCCHHCCEEEEE		52.7022790023
4304AcetylationWRQNKFGKGNKEKLL
CCCCCCCCCCCCEEE		63.547713861
4307AcetylationNKFGKGNKEKLLVVN
CCCCCCCCCEEEEEC		65.977713871
4309AcetylationFGKGNKEKLLVVNPW
CCCCCCCEEEEECHH		49.057713881
4329N-linked_GlycosylationIFHQLRYNQSVSNPC
HHHHHHCCCCCCCHH		22.63-
4451UbiquitinationVGFFHYRKTGSLLPS
HHHHHHHCCCCCCCC		50.5022790023
4458PhosphorylationKTGSLLPSLPKLPSL
CCCCCCCCCCCCCCH		58.2225195567
4464PhosphorylationPSLPKLPSLSSLAKP
CCCCCCCCHHHCCCC		51.8528978645
4466PhosphorylationLPKLPSLSSLAKPSE
CCCCCCHHHCCCCCC		27.8717203969
4467PhosphorylationPKLPSLSSLAKPSEN
CCCCCHHHCCCCCCC		37.3222817900
4470UbiquitinationPSLSSLAKPSENGNG
CCHHHCCCCCCCCCC		55.1322790023
4472PhosphorylationLSSLAKPSENGNGVT
HHHCCCCCCCCCCCE		42.8817203969
4517UbiquitinationQFVMEVGKQPVIFEN
HHHHHCCCCCEEEEC		57.5122790023
4530UbiquitinationENPMYAAKDSTSKVG
ECCEEECCCCCCCCE		44.0022790023
4532PhosphorylationPMYAAKDSTSKVGLA
CEEECCCCCCCCEEE		33.6021082442
4533PhosphorylationMYAAKDSTSKVGLAV
EEECCCCCCCCEEEE		42.5821183079
4534PhosphorylationYAAKDSTSKVGLAVQ
EECCCCCCCCEEEEE		29.3321183079
4535UbiquitinationAAKDSTSKVGLAVQG
ECCCCCCCCEEEEEC		40.1722790023
4560PhosphorylationENVENQNYGRSIDPS
CCCCCCCCCCCCCHH		12.26-
4577PhosphorylationVPEPKPASPGADETQ
CCCCCCCCCCCCCCC		32.1827180971
4583PhosphorylationASPGADETQGTKWNI
CCCCCCCCCCCCCCC		32.6126239621
4586PhosphorylationGADETQGTKWNIFKR
CCCCCCCCCCCCCCC		24.0626239621
4587UbiquitinationADETQGTKWNIFKRK
CCCCCCCCCCCCCCC		45.1022790023
4598PhosphorylationFKRKPKQTTNFENPI
CCCCCCCCCCCCCCC		29.8122817900
4599PhosphorylationKRKPKQTTNFENPIY
CCCCCCCCCCCCCCE		35.1022817900
4606PhosphorylationTNFENPIYAEMDTEQ
CCCCCCCEEECCCCC		9.58-
4624PhosphorylationVAVAPPPSPSLPAKA
EEECCCCCCCCCCHH		32.6626824392
4626PhosphorylationVAPPPSPSLPAKASK
ECCCCCCCCCCHHCC		51.8526239621
4632PhosphorylationPSLPAKASKRSSTPG
CCCCCHHCCCCCCCC		28.0922817900
4635PhosphorylationPAKASKRSSTPGYTA
CCHHCCCCCCCCCCC		42.1521183079
4636PhosphorylationAKASKRSSTPGYTAT
CHHCCCCCCCCCCCC		42.5327180971
4637PhosphorylationKASKRSSTPGYTATE
HHCCCCCCCCCCCCC		23.2126239621
4640PhosphorylationKRSSTPGYTATEDTF
CCCCCCCCCCCCCHH		8.3921183079
4643PhosphorylationSTPGYTATEDTFKDT
CCCCCCCCCCHHHHH		26.9620139300
4648UbiquitinationTATEDTFKDTANLVK
CCCCCHHHHHHHHCC		57.1522790023
4655UbiquitinationKDTANLVKEDSDV--
HHHHHHCCCCCCC--		59.9922790023
4658PhosphorylationANLVKEDSDV-----
HHHCCCCCCC-----		41.1719060867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DC1I2_MOUSEDync1i2physical
23836931
ARH_MOUSELdlrap1physical
23836931
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRP2_MOUSE

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-387 AND ASN-399, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4464 AND SER-4472, ANDMASS SPECTROMETRY.

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