DC1I2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC1I2_MOUSE
• UniProt AC: O88487
• Protein Name: Cytoplasmic dynein 1 intermediate chain 2
• Gene Name: Dync1i2
• Organism: Mus musculus (Mouse).
• Sequence Length: 612
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)..
• Protein Sequence: MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAAVSVQEESDLEKKRREAEALLQSMGLTTDSPIVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRRGPIKLGMAKITQVDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVATPKPPVEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRADAEEEAATRIPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDKSDLKA ------CCCHHHHHH	54.46	-
2	Phosphorylation	------MSDKSDLKA ------CCCHHHHHH	54.46	29176673
46	Phosphorylation	QKKEAAVSVQEESDL HHHHHHHHHHCHHHH	17.23	23984901
51	Phosphorylation	AVSVQEESDLEKKRR HHHHHCHHHHHHHHH	46.90	25521595
66	Phosphorylation	EAEALLQSMGLTTDS HHHHHHHHCCCCCCC	18.13	25619855
70	Phosphorylation	LLQSMGLTTDSPIVP HHHHCCCCCCCCCCC	23.87	25619855
71	Phosphorylation	LQSMGLTTDSPIVPP HHHCCCCCCCCCCCC	39.25	25619855
73	Phosphorylation	SMGLTTDSPIVPPPM HCCCCCCCCCCCCCC	17.90	25619855
81	Phosphorylation	PIVPPPMSPSSKSVS CCCCCCCCCCCCCCC	27.66	27087446
83	Phosphorylation	VPPPMSPSSKSVSTP CCCCCCCCCCCCCCC	42.99	22942356
84	Phosphorylation	PPPMSPSSKSVSTPS CCCCCCCCCCCCCCC	32.13	27087446
86	Phosphorylation	PMSPSSKSVSTPSEA CCCCCCCCCCCCCCC	24.21	27087446
88	Phosphorylation	SPSSKSVSTPSEAGS CCCCCCCCCCCCCCC	41.51	23684622
89	Phosphorylation	PSSKSVSTPSEAGSQ CCCCCCCCCCCCCCC	28.78	25521595
91	Phosphorylation	SKSVSTPSEAGSQDS CCCCCCCCCCCCCCC	39.92	27742792
95	Phosphorylation	STPSEAGSQDSGDGA CCCCCCCCCCCCCCC	37.55	25521595
98	Phosphorylation	SEAGSQDSGDGAVGS CCCCCCCCCCCCCCC	31.01	25521595
105	Phosphorylation	SGDGAVGSRRGPIKL CCCCCCCCCCCCCEE	16.53	25619855
129	Phosphorylation	FPPREIVTYTKETQT CCCHHEEEEECCCCC	31.00	28576409
131	Phosphorylation	PREIVTYTKETQTPV CHHEEEEECCCCCCC	17.03	28576409
134	Phosphorylation	IVTYTKETQTPVTAQ EEEEECCCCCCCCCC	39.02	25777480
136	Phosphorylation	TYTKETQTPVTAQPK EEECCCCCCCCCCCC	27.44	25777480
139	Phosphorylation	KETQTPVTAQPKEDE CCCCCCCCCCCCCCC	22.30	25777480
154	Phosphorylation	EEEDDVATPKPPVEP CCCCCCCCCCCCCCH	31.52	25521595
229	Ubiquitination	SGRDLEDKEGEIQAG CCCCCCCCCCCCCCC	59.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
81	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
81	S	Phosphorylation	Kinase	AMPKA2	P54646	PSP
81	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	S	Phosphorylation	The phosphorylation status of Ser-84 appears to be involved in dynactin-dependent target binding.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC1I2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYLT3_HUMAN	DYNLT3	physical	20360068
DLRB1_HUMAN	DYNLRB1	physical	20360068
DC1L2_HUMAN	DYNC1LI2	physical	20360068
DC1I2_HUMAN	DYNC1I2	physical	20360068
DYHC1_HUMAN	DYNC1H1	physical	20360068
DYL1_HUMAN	DYNLL1	physical	20360068
DC1L1_HUMAN	DYNC1LI1	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.